58587-04-5

Upstream product

• 98-89-5 Cyclohexanecarboxylic acid 
• 2637-34-5 2-Sulfanylpyridine 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 2127-03-9 2,2'-dipyridyldisulphide 
• 60718-45-8 1-cyclohexanecarbonyl-1H-imidazole 
• 25666-60-8 potassium 1-cyclohexyl methanoate 
• 128100-67-4 1,2-bis(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)ethane-1,2-dione 

Downstream Products

• 7469-80-9 cyclohexyl 4-methoxyphenyl ketone 
• 85014-02-4 cyclohexyl-(4-fluoromethyl)methanone 
• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 110-83-8 cyclohexene 
• 55409-09-1 1,2-dicyclohexyl-2-hydroxy-ethanone 
• 951-88-2 1,2-dicyclohexylethanedione 
• 75211-59-5 cyclohexyl-(1H-pyrrol-2-yl)methanone 

Relevant academic research and scientific papers

Cobalt-catalyzed acylation-reactions of (hetero)arylzinc pivalates with thiopyridyl ester derivatives

A cobalt-catalyzed acylation reaction of various primary, secondary and tertiary alkyl, benzyl and (hetero)aryl S-pyridyl thioesters with (hetero)arylzinc pivalates is reported. The thioesters were prepared directly from the corresponding carboxylic acids under mild conditions, thus tolerating sensitive functional groups. Acylations of α-chiral S-pyridyl esters proceeded with very high stereoretention leading to optically enriched α-chiral ketones.

Light-Driven Vitamin B12-Catalysed Generation of Acyl Radicals from 2-S-Pyridyl Thioesters

Acyl radicals are invaluable intermediates in organic synthesis, however their generation remains challenging. Herein, we present an unprecedented light-driven, cobalt-catalysed method for the generation of acyl radicals from readily available 2-S-pyridyl thioesters. The synthetic potential of this methodology was demonstrated in the Giese-type acylation of activated olefins in the presence of heptamethyl cobyrrinate. This vitamin B12 derivative proved to be the most efficient catalyst in the studied process. The developed method features broad substrate scope (38 examples), good functional group tolerance, and mild reaction conditions. Moreover, it is easily scalable (illustrated on a 20-fold scale-up procedure), enabling its preparative use. Mechanistic studies revealed that the reaction proceeds via a radical pathway with the key steps involving the formation of an acyl-vitamin B12 complex and subsequent photolysis of the Co?C bond. (Figure presented.).

Synthesis of Thiol Esters by Carboxylic Trichlorobenzoic Anhydrides

Thiocarboxylic S-esters were obtained rapidly and in high yields by treating the mixed anhydrides prepared from 2,4,6-trichlorobenzoyl chloride and carboxylic acid, with various types of thiols in the presence of 4-dimethylaminopyridine.

A CONVENIENT ONE-POT PROCEDURE FOR SYNTHESIS OF THIOL ESTERS USING MAGNESIUM ION AS A CATALYST

Various thiol esters (R1COSR2) were prepared in high yields by treatment of 1-acylimidazole with thiols in the presence of a catalytic amount of Mg(OEt)2.Malonic half-thiol esters 1OCOCH(R3)COSR2> were also prepared in good yields by treating magnesium monoalkyl malonate 1OCOCH(R3)COOMg0.5> with carbonyl-1,1'-diimidazole followed by addition of thiols.