58609-02-2

Basic information

• Product Name: N-(4-chlorophenyl)-3-(4-hydroxyphenyl)propanamide
• CAS NO: 58609-02-2
• Molecular Weight: 275.735
• Mol File: 58609-02-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-chlorophenyl)-3-(4-hydroxyphenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-3-(4-hydroxyphenyl)propanamide(58609-02-2)
• EPA Substance Registry System: N-(4-chlorophenyl)-3-(4-hydroxyphenyl)propanamide(58609-02-2)

Safety Data

• Hazardous Substances Data: 58609-02-2(Hazardous Substances Data)

Upstream product

• 501-97-3 4-hydroxyphenylpropionic acid 
• 106-47-8 4-chloro-aniline 
• 58608-98-3 3-<4-(benzyloxy)phenyl>-propanoyl chloride 
• 50463-48-4 3-(4-benzyloxyphenyl)propanoic acid 
• 58609-01-1 3-(4-Benzyloxy-phenyl)-N-(4-chloro-phenyl)-propionamide 

Downstream Products

• 58609-00-0 2-{4-[2-(4-Chloro-phenylcarbamoyl)-ethyl]-phenoxy}-2-methyl-propionic acid ethyl ester 
• 58609-10-2 {4-[2-(4-Chloro-phenylcarbamoyl)-ethyl]-phenoxy}-acetic acid ethyl ester 
• 58609-34-0 {4-[2-(4-Chloro-phenylcarbamoyl)-ethyl]-phenoxy}-acetic acid 
• 58609-38-4 2-{4-[2-(4-Chloro-phenylcarbamoyl)-ethyl]-phenoxy}-2-methyl-propionic acid 

Relevant articles and documents

Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase

Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Unsaturated fatty acids are required for membrane integrity and for cell proliferation. For these reasons, inhibitors of SCD represent potential treatments for cancer. However, systemically active SCD inhibitors result in skin toxicity, which presents an obstacle to their development. We recently described a series of oxalic acid diamides that are converted into active SCD inhibitors within a subset of cancers by CYP4F11-mediated metabolism. Herein, we describe the optimization of the oxalic acid diamides and related N-acyl ureas and an analysis of the structure-activity relationships related to metabolic activation and SCD inhibition.