58644-57-8

Basic information

• Product Name: Formamide, N-(2-hydroxy-2-phenylethyl)-
• CAS NO: 58644-57-8
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Mol File: 58644-57-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Formamide, N-(2-hydroxy-2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N-(2-hydroxy-2-phenylethyl)-(58644-57-8)
• EPA Substance Registry System: Formamide, N-(2-hydroxy-2-phenylethyl)-(58644-57-8)

Safety Data

• Hazardous Substances Data: 58644-57-8(Hazardous Substances Data)

Upstream product

• 21857-14-7 5-Phenyl-2-oxazoline 
• 146039-03-4 N-(Diethylcarbamoyl)-N-methoxyformamide 
• 7568-93-6 2-Amino-1-phenylethanol 
• 201230-82-2 carbon monoxide 
• 68-12-2 N,N-dimethyl-formamide 
• 100-52-7 benzaldehyde 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 64-18-6 formic acid 
• 64-17-5 ethanol 
• 73286-37-0 N-(2-oxo-2-phenylethyl)formamide 

Downstream Products

• 63784-37-2 (5R)-6t-(2-formylamino-1-phenyl-ethoxycarbonylmethyl)-3,3-dimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 119-65-3 isoquinoline 

Relevant articles and documents

METHOD OF CARBON MONOXIDE FIXATION AND METHOD OF AMINE FORMYLATION

The present invention relates to a method for fixing carbon monoxide in a metal-free condition and a method for formating amine using the same.

Catalyst-Free Transamidation of Aromatic Amines with Formamide Derivatives and Tertiary Amides with Aliphatic Amines

A simple catalyst- and promoter-free protocol has been developed for the transamidation of weakly nucleophilic aromatic amines with formamide derivatives and low-reactivity tertiary amides with aliphatic amines. This strategy is advantageous because no catalyst or promoters are needed, no additives are required, separation and purification is easy, and the reaction is scalable. Significantly, this strategy was further applied to synthesize several pharmaceutical molecules on a gram scale, and excellent yields were achieved.

Method for synthesizing formamide derivative through Mn-catalyzed formylation reaction

The invention discloses a method for synthesizing a formamide derivative through Mn-catalyzed formylation reaction. The method disclosed by the invention is characterized in that an amine compound anda formamide compound are subjected to one-pot reaction under the catalytic action of manganese salt to generate the formamide derivative. The method disclosed by the invention has the beneficial effects that reaction raw materials and a catalyst are cheap and easy to get, reaction steps and operation are simple, the advantages of high reaction selectivity, high yield and expandable reaction are achieved, and the defects that a reagent is high in toxicity, the catalyst is expensive, reaction steps are tedious and byproducts are more in the prior art are overcome.