73286-37-0

Basic information

• Product Name: N-(2-o×o-2-phenyl-ethyl)forMaMide
• Synonyms: N-(2-Oxo-2-phenylethyl)forMaMide;N-(2-Oxo-2-phenylethyl);ForMaMide, N-(2-o×o-2-phenylethyl)-;N-(2-o×o-2-phenyl-ethyl)forMaMide;N-phenacylformamide
• CAS NO: 73286-37-0
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17326
• Mol File: 73286-37-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 70-71 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• Boiling Point: 387.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.136±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 14.58±0.23(Predicted)
• CAS DataBase Reference: N-(2-o×o-2-phenyl-ethyl)forMaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-o×o-2-phenyl-ethyl)forMaMide(73286-37-0)
• EPA Substance Registry System: N-(2-o×o-2-phenyl-ethyl)forMaMide(73286-37-0)

Safety Data

• Hazardous Substances Data: 73286-37-0(Hazardous Substances Data)

Usage

General Description

N-(2-oxo-2-phenylethyl)formamide is a chemical compound with the molecular formula C9H9NO2. It is an amide derivative of phenethylamine and is commonly used in organic synthesis as a building block for the production of various pharmaceuticals and agrochemicals. N-(2-o×o-2-phenyl-ethyl)forMaMide may also have potential applications in the field of medicinal chemistry due to its structural properties and biological activities. It is important to handle this chemical with caution and to follow proper safety protocols when working with it in laboratory settings.

Upstream product

• 64-18-6 formic acid 
• 1816-88-2 2-azido-1-phenylethan-1-one 
• 100-42-5 styrene 
• 102921-26-6 (1,2-dibromoethyl)benzene 
• 29847-04-9 1-(1-azido-2-bromoethyl)benzene 
• 16717-64-9 1-azidostyrene 
• 7654-06-0 3-phenyl-2H-azirine 
• 70-11-1 α-bromoacetophenone 
• 18197-26-7 sodium diformamide 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 122-51-0 orthoformic acid triethyl ester 
• 127118-86-9 2-diformylamino-1-phenylethanone 

Downstream Products

• 102831-17-4 N-(1-Benzoyl-pentyl)-formamide 
• 102831-15-2 N-(1-Benzoyl-propyl)-formamide 
• 1006-68-4 5-phenyloxazole 
• 1826-13-7 5-phenylthiazole 
• 1823-83-2 2-Phenylvinyl Isocyanide 
• 119-65-3 isoquinoline 
• 77184-09-9 N-(β-Hydroxyphenaethyl)-N-methyl-carbaminsaeure-(t-butyl)ester 
• 77184-10-2 1,1-dimethylethyl methyl(2-phenyl-2-oxoethyl)carbamate 
• 77184-12-4 rac-3-hydroxy-1-methyl-3-phenylazetidin-2-one 
• 76467-28-2 N-Methyl-N-phenacylformamid 
• 102831-11-8 2-Amino-1,3-diphenyl-propan-1-one; hydrobromide 
• 58644-57-8 N-(2-hydroxy-2-phenylethyl)formamide 
• 3755-86-0 β-Chlor-β-phenyl-aethylisonitril 
• 102831-14-1 N-(1-oxo-1-phenylpropan-2-yl)formamide 

Relevant articles and documents

Synthesis of α-Amidoketones through the Cascade Reaction of Carboxylic Acids with Vinyl Azides under Catalyst-Free Conditions

An efficient synthesis of α-amidoketone derivatives through the cascade reactions of carboxylic acids with vinyl azides is presented. Compared with literature protocols, notable features of this new method include catalyst-free conditions, broad substrate scope, good tolerance of a wide range of functional groups, and high efficiency. In addition, the synthetic potential of this method as a tool for late-stage modification was convincingly manifested by its application in the structural elaborations of a number of carboxylic acid drug molecules.

Synthesis method of alpha-acylamino ketone compound

The invention discloses a synthesis method of an alpha-acylamino ketone compound, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: mixingan alkenyl azide compound 1, a carboxylic acid compound 2 and an organic solvent, and heating to react to obtain the alpha-acylamino ketone compound 3. Compared with the prior art, the method has thefollowing advantages: (1) the synthesis process is simple and efficient, no catalyst is needed in the whole process, and the alpha-acylamino ketone compound can be obtained with high yield by dissolving the alkenyl azide compound and the carboxylic acid compound in the solvent and stirring; (2) raw materials are cheap and easy to obtain, reaction conditions are mild, and operation is simple; (3) the substrate is wide in application range and can be used for modifying drug molecules; and (4) the atom economy is high, and the requirements of green chemistry are met.

A CONVENIENT PREPARATION OF AMINOMETHYL ARYL KETONES AND THEIR DERIVATIVES

A convenient preparation of N-phenacyl diformamides, N-phenacyl formamides and aminomethyl aryl ketone hydrochlorides from aryl bromomethyl ketones and sodium diformylamide was described.