58647-73-7

Upstream product

• 412027-46-4 2-(4-methoxy-benzyl)-adipic acid 
• 108-24-7 acetic anhydride 
• 7148-07-4 1-pyrrolidinocyclopent-1-ene 
• 824-94-2 p-methoxybenzyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 120-92-3 cyclopentanone 
• 25786-65-6 1-(4-methoxy-benzyl)-2-oxo-cyclopentanecarboxylic acid ethyl ester 
• 105-13-5 4-Methoxybenzyl alcohol 
• 5405-95-8 4,4'-dimethoxydibenzyl ether 
• 19980-43-9 1-(trimethylsilyloxy)cyclopentene 
• 104-21-2 p-methoxybenzyl acetate 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 73403-12-0 2-(4-Methoxy-benzyl)-2,5,5-trimethyl-cyclopentanone 
• 336884-10-7 tetrahydro-6-[(4-methoxyphenyl)methyl]-2H-pyran-2-one 
• 158096-72-1 ethyl N-(2-<4-(2-oxocyclopent-1-ylmethyl)phenoxy>ethyl)carbamate 
• 158096-93-6 ethyl 2-<4-(2-oxocyclopent-1-ylmethyl)phenoxy>ethyl carbonate 
• 120647-36-1 2-(4-hydroxybenzyl)cyclopentan-1-one ethylene acetal 
• 84715-32-2 2-(4-hydroxybenzyl)cyclopentan-1-one 

Relevant academic research and scientific papers

Palladium-catalyzed cross-coupling of cyclopropanol-derived ketone homoenolates with aryl bromides

The cross-coupling reaction of cyclopropanol-derived ketone homoenolates bearing β-hydrogens with aryl and hetaryl bromides has been achieved for the first time. This reaction is high yielding, is broad in scope and uses a simple catalytic system. Notably, the proposed palladium homoenolates do not undergo β-hydride elimination to the corresponding α,β- unsaturated ketones.

Trialkylsilyl triflimides as easily tunable organocatalysts for allylation and benzylation of silyl carbon nucleophiles with non-genotoxic reagents

Trialkylsilyl triflimides generated in situ are unique catalysts for the electrophilic benzylation or allylation of trialkylsilylenol ethers or allyl trialkylsilanes with non-genotoxic alkylating reagents such as benzyl and allyl acetates. In most cases the reactions are fast at room temperature and yields are high. The reaction works particularly well with electron-rich benzyl donors including derivatives of pyrrole, indole and furane.

Chemo- and diastereoselective Bi(OTf)3-catalyzed benzylation of silyl nucleophiles

The direct alkylation of silyl enol ethers with para-methoxybenzylic alcohols or their corresponding acetates was efficiently catalyzed by Bi(OTf)3 in CH3NO2 as the solvent. The reaction provided the α-benzylated carbonyl

METHOD FOR ESTABLISHING CC BONDS BETWEEN ELECTROPHILIC SUBSTRATES AND ? - NUCLEOPHILES IN NEUTRAL TO ALKALINE AQUEOUS OR ALCOHOLIC SOLVENTS WITHOUT USING A LEWIS OR BRONSTED ACID

The invention relates to a method for establishing carbon-carbon bonds by reacting electropohilic substrates that have a solvolysis rate kEtOH (25°C) > 10-6 s-1 and ? compounds. The method is characterized by generating the intermediary carbocations in neutral to alkaline aqueous or alcoholic solvents or solvent mixtures without using a Lewis or Br?nsted acid.

Tandem hemiketal formation-intramolecular Friedel-Crafts alkylation: A facile route to hetero-atom-substituted benzo-fused bicyclo[3.3.1]nonanes

A previously unknown intramolecular Friedel-Crafts alkylation with in situ formed hemiketals as the electrophile is reported.

Synthesis and structure-activity relationships of juvenoids derived from 2-(4-hydroxybenzyl)cycloalkan-1-ones

Juvenoids 16-30, 32, 36, 38-41, 44-46, and 49-56 containing carbamate, carbonate, and urea moieties in the molecule were synthesized and subjected to a biological screening. Carbamate juvenoids 1-4 were used as reference compounds for a detailed structure-activity study of their analogues. A clear relationship between the nature of the side chain functional group and the biological activity was found. Surprisingly, not only the juvenoids 1,4 but also 38-41, the compounds with a reversed carbamate N,O-substitution pattern, showed very promising biological activity. In contrast, the carbonate and urea derivatives displayed a remarkably low activity. The relationship between the size and substitution at atoms C(2) and C(3) of the saturated ring and the biological activity is very complex and is still not completely understood.