58656-16-9

Upstream product

• 1122-93-6 potassium p-methoxyphenolate 
• 88-73-3 2-Chloronitrobenzene 
• 150-76-5 4-methoxy-phenol 
• 19013-30-0 p-methoxyphenyl mesylate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 62790-87-8 4-(tert-butyldimethylsilyloxy)anisole 
• 577-19-5 2-nitrophenyl bromide 
• 23530-43-0 2-(N,N-dimethylaminosulfonyl)nitrobenzene 

Downstream Products

• 105901-39-1 2-(4-Methoxyphenoxy)benzenamine 
• 860518-95-2 1-(4-iodo-2-nitro-phenoxy)-4-methoxy-benzene 
• 58400-34-3 2,2-dimethoxy-3-(4-methoxy-phenyl)-2-phenyl-2,3-dihydro-2λ⁵-benzo[1,3,2]oxazaphosphole 
• 58656-31-8 2-Ethoxy-4'-methoxydiphenylamin 
• 58656-42-1 3-(4-methoxy-phenyl)-2-methyl-2,3-dihydro-benzo[1,3,2]oxazaphosphole 2-oxide 
• 721448-65-3 N-(2-(4-methoxyphenoxy)phenyl)methanesulfonamide 
• 51765-76-5 N-(2-(4-methoxyphenoxy)-4-nitrophenyl)methanesulfonamide 
• 109032-22-6 4-Hydroxy-Nimesulide 
• 860525-82-2 dichloro-[2-(4-methoxy-phenoxy)-phenyl]-arsine 
• 860517-52-8 [2-(4-methoxy-phenoxy)-phenyl]-arsonic acid 
• 54582-58-0 4-hydroxy-2'-nitrodiphenyl ether 
• 1379658-94-2 ((2-(4-methoxyphenoxy)phenyl)ethynyl)trimethylsilane 
• 1379658-95-3 1-ethynyl-2-(4-methoxyphenoxy)benzene 
• 1379658-69-1 rac-(2-bromo-4-methylphenoxy)-4-(2-(4-methoxyphenoxy)phenyl)but-3-yn-2-ol 

Relevant academic research and scientific papers

Design, synthesis and antifungal activity of novel furancarboxamide derivatives

Twenty-seven novel furancarboxamide derivatives with a diphenyl ether moiety were synthesized and evaluated for their antifungal activity against Rhizoctonia solani, Botrytis cirerea, Valsa Mali and Sphaceloma ampelimum. Antifungal bioassay results indicated that most compounds had good or excellent fungicidal activities for R. solani and S. ampelimum at 20 mg L-1. Among synthesized compounds, compound 18e showed a greater inhibitory effect against S. ampelimum, with half maximal effective concentration (EC50) values of 0.020 mg L-1. This strong activity rivals currently used commercial fungicides, such as Boscalid and Carbendazim, and has great potential as a lead compound for future development of novel fungicides.

NEW MACROCYCLIC COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

A compound of formula (I) : wherein Z, Y1,Y2,(Formula II)R1 to R7 are as defined in the description, its optical isomers, and addition salts thereof with a pharmaceutically acceptable base. Medicaments.

A novel magnetic polyacrylonotrile-based palladium Core?Shell complex: A highly efficientcatalyst for Synthesis of Diaryl ethers

The present article describes the synthesis of a new magnetic polyacrylonitrile-based Pd catalyst involving polyacrylonitrile modified via 2-aminopyridine as an efficient support to immobilize Pd nanoparticles. The simple reusability, easy separation and high stability of this Pd complex make it an excellent candidate to generate a C–O bond via Ph-X activation which is a really important subject in achieving biologically active compounds. It is worth to note access to good and high yields as well as broad substrate scope have resulted from superior reactivity of this catalyst complex. Furthermore, the structure of the magnetic polyacrylonitrile-based heterogeneous catalyst was characterized by fourier transmission infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM), X-ray diffraction (XRD). Also, its thermal properties were studied by thermogravimetric analysis (TGA).

Ligand-free copper-catalyzed O-arylation of arenesulfonamides with phenols: An unusual approach to biaryl ether synthesis

An unprecedented ligand-free copper-catalyzed O-arylation of arenesulfonamides with phenols has been developed. Thus, a range of unsysmmetric biaryl ethers were synthesized in excellent yields. The reaction occurs efficiently with excellent regioselectivity through the cleavage of Cary–S bond and with a good tolerance of functional groups on the phenyl ring of phenols. The reaction is appreciated for its readily accessible substrates, mild conditions, and simple operation under air.

Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop

Microtubule targeting agents represent a very active arena in the development of anticancer agents. In particular, compounds binding at the colchicine site in tubulin are being deeply studied, and the structural information recently available on this binding site allows structure-directed design of new ligands. Structural comparison of our recently reported high resolution X-Ray structure of the cyclohexanedione derivative TUB075 bound to tubulin and the tubulin-DAMA-colchicine complex has revealed a conformational change in the αT5 loop. By a grid-based computational analysis of the tubulin-DAMA-colchicine binding site, we have identified a new favourable binding area in the colchicine-site that was unexplored by our lead TUB075. Thus, based on a structure-guided design, new cyclohexanedione derivatives have been synthesized and tested for tubulin binding and in cellular assays. As a result, we have identified diphenyl ether derivatives with IC50 values around 10–40 nM against three different tumor cell lines and affinity constants for tubulin similar to that of colchicine around 107 M?1. As expected, they halted the cell cycle progression at G2/M phase at concentrations as low as 0.08 μM.

Immobilized palladium nanoparticles on MNPs@A-N-AEB as an efficient catalyst for C-O bond formation in water as a green Solvent

Palladium nanoparticles immobilized on the magnetic nanoparticles@2-amino-N-(2-aminoethyl) benzamide (MNPs@A-N-AEB.Pd0) have been presented as an efficient, and reusable magnetically heterogeneous catalyst for the C-O coupling reaction, namely Ullmann condensation reactions in an aqueous medium. This heterogeneous catalyst shows superior reactivity for the C-O arylation of different aryl halide (chloride, bromide, and iodide) with phenol derivatives to afford the desired products in good to excellent yields within short reaction time. Moreover, the catalyst can be easily recovered and reused for seven runs without loss of catalytic activity. The catalyst was characterized by several techniques, such as FT-IR, SEM, TEM, EDS, XRD, TGA and ICP-OES.

Synthesis of near-infrared fluorescent rhodamines via an SNArH reaction and their biological applications

Near-infrared (NIR) dyes are of great interest in biomedicine due to diminished interfering absorption and fluorescence from biological samples, reduced scattering, and enhanced tissue penetration depth. In this context, we report the synthesis of rectili

Linear type Pi-expanded xanthene dyes and preparation method thereof

The invention provides linear type Pi-expanded xanthene dyes. The linear type Pi-expanded xanthene dyes have emission wavelength located in deep-infrared and near-infrared regions and have a general structural formula as described in the specification. In the general structural formula, Ar is selected from the group consisting of a benzene ring, a pyridine ring, a quinoline ring and a naphthalenering; R is selected from the group consisting of H, a methoxy group, an amino group, a cyano group and a trifluoromethyl group; and R' is selected from the group consisting of a methyl group and an ethyl group. The preparation method for one linear type Pi-expanded xanthene dye comprises the following steps: pre-assembling an aromatic ring with an amino group at an ortho position to the C-6 position of a xanthene dye, and then allowing the amino group on the aromatic ring to nucleophilically substitute a hydrogen atom at the C-7 position of xanthene to form a C-N bond so as to synthesize the linear type Pi-expanded xanthene fluorescent dye. The invention has the following advantages: a series of the dyes prepared by using the method provided by the invention have good membrane permeabilityand can be used for cell imaging; and the preparation method is simple and convenient, does not need high temperature and high pressure in the preparation process, does not use extremely flammable and explosive chemicals, has low danger coefficient, needs no expensive metal for a catalytic reaction, and is easy to promote and use.

Synthesis of medium-sized (6-7-6) ring compounds by iron-catalyzed dehydrogenative C-H activation/annulation

In this report, we have described a FeCl3-catalyzed process involving intramolecular annulation of o-phenoxy diarylacetylenes via hydroarylation to afford a series of biologically potent fused seven-membered (6-7-6) ring compounds under mild reaction conditions. This reaction was believed to proceed through Friedel-Crafts type sequential carbometallation followed by protonation to produce phenyldibenz[b,f]oxepines. This method was also extended to synthesize seven-membered rings that are fused with coumarins.

Ligand free copper-catalyzed heterogeneous O-arylation reaction under green condition

A highly porous Zn-based iso-reticular metal-organic framework (IRMOF-3) has been selected for covalent modification. Pyridine-2-aldehyde has been used to decorate the free amine group of IRMOF-3 in the porous matrix. Schiff base moiety thus generated has been availed to anchor copper(II) ions to prepare the desired catalyst that catalyzes O-arylation reactions heterogeneously under mild reaction conditions. Porous catalyst demonstrates size selectivity in products when various substrates undergo O-arylation with α and β-naphthol.