58656-97-6

Upstream product

• 19924-43-7 3-methoxyphenylacetonitrile 
• 23194-66-3 3-methoxybenzoyl cyanide 
• 75-65-0 tert-butyl alcohol 
• 83766-88-5 2-tert-butoxypyridine 
• 586-38-9 3-Methoxybenzoic acid 
• 766-85-8 3-methoxy-1-iodobenzene 
• 201230-82-2 carbon monoxide 
• 865-47-4 potassium tert-butylate 
• 65853-67-0 3-methoxybenzoic acid phenyl ester 
• 163396-66-5 3-t-butoxy-4,4-diisopropyl-3-(3-methoxyphenyl)-1,2-dioxetane 

Downstream Products

• 163396-55-2 1-(1-tert-Butoxy-2-isopropyl-3-methyl-but-1-enyl)-3-methoxy-benzene 
• 586-38-9 3-Methoxybenzoic acid 

Relevant academic research and scientific papers

A Cyanide-Free Synthesis of Acylcyanides through Ru-Catalyzed C(sp3)-H-Oxidation of Benzylic Nitriles

A practical method for generation of acylcyanides devoid of any external cyanide sources is presented that relies on a mild Ru-catalyzed selective C?H-oxidation of benzylic nitriles. The starting materials are smoothly generated through condensation of the corresponding carboxylic acid amides using silanes. The obtained acylcyanides can be employed in a plethora of transformation as exemplified to some larger extend in the sequence of C?H-oxidation-Tischenko-rearrangement for the generation of structurally diverse benzoyloxycyanohydrines.

A fast and practical synthesis of tert-butyl esters from 2-tert-butoxypyridine using boron trifluoride·diethyl etherate under mild conditions

A practical direct preparation of tert-butyl esters from 2-tert-butoxypyridine has been developed. This system features the use of boron trifluoride·diethyl etherate in toluene solvent to rapidly achieve the reaction at room temperature. Using this reaction protocol, a variety of tert-butyl esters were synthesized from several different carboxylic acids at high yields. This practical procedure provides a promising and effective approach to the protection of carboxylic acids with a tert-butyl group.

Transition-metal-free alkoxycarbonylation of aryl halides

Transitions: The title reaction has been developed for the synthesis of a variety of tert-butyl benzoates by employing 1,10-phenanthroline as an additive. Various functional groups were tolerated and heteroaryl iodides were also suitable substrates. Preli

Carbonylation of aryl chlorides with oxygen nucleophiles at atmospheric pressure. Preparation of phenyl esters as acyl transfer agents and the direct preparation of alkyl esters and carboxylic acids

(Chemical Equation Presented) A mild, functional group tolerant method of the preparation of phenyl esters from aryl chlorides via palladium-catalyzed carbonylation is described using atmospheric pressure of carbon monoxide. Phenyl esters are shown to be useful acylating agents, delivering libraries of carbonyl derivatives, including alkyl, allyl and thioesters, under very mild conditions. Direct preparation of alkyl esters and carboxylic acids is also demonstrated, providing the first method for the preparation of methyl and ethyl esters from aryl chlorides without pressured reactors.

1,2-dioxetane derivatives, intermediates for syntheses thereof and methods of producing the intermediates

A chemiluminescent 1,2-dioxetane derivative having a formula (I): STR1 wherein R1 and R4 each represent, individually, hydrogen, an alkyl group, an alkoxyl group, a hydroxyl group, or --OSi(R9 R10 R11) in which R9, R10 and R11 each represent an alkyl group; R2, R3, R5 and R6 each represent, individually, hydrogen or an alkyl group, provided that R2, R3, R5 and R6 each cannot be hydrogen at the same time, and that R2 and R3, and R5 and R6, each taken together, can form a cycloalkyl group; R7 represents an alkyl group; R8 represents hydrogen, an alkoxyl group, a phosphate salt group, or --OSi(R9 R10 R11); intermediates for synthesizing the above 1,2-dioxetane derivative; and methods of producing the intermediates are provided.

Thermal Stability and Chemiluminescence of 3-Alkoxy-3-aryl-4,4-diisopropyl-1,2-dioxetanes

The singlet oxygenation of alkenes 1 gives the corresponding dioxetanes 2, whose thermal stability and half-life of chemiluminescence induced by TBAF (NBun4F) are significantly affected by the 3-alkoxyl group.