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Usage

Uses

Used in Organic Synthesis:
4-CHLORO-2-(METHYLTHIO)QUINAZOLINE is used as a building block for the synthesis of various pharmaceutical and agrochemical products. Its unique structure allows for the creation of a wide range of compounds with potential applications in different industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-CHLORO-2-(METHYLTHIO)QUINAZOLINE is used as a versatile intermediate for the development of new compounds with potential biological activities. Its presence in the molecular structure can contribute to the desired pharmacological properties of the final product.
Used in Research:
4-CHLORO-2-(METHYLTHIO)QUINAZOLINE is also used as a research tool in the investigation of quinazoline-based drug candidates. Its unique properties make it valuable for studying the structure-activity relationships and optimizing the potency and selectivity of these drug candidates.
Used in Pharmaceutical Industry:
4-CHLORO-2-(METHYLTHIO)QUINAZOLINE is used as a key intermediate in the synthesis of various pharmaceutical products. Its incorporation into the molecular structure of these products can enhance their therapeutic efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical industry, 4-CHLORO-2-(METHYLTHIO)QUINAZOLINE is used as a building block for the development of new agrochemical products. Its unique structure can contribute to the creation of compounds with improved pesticidal or herbicidal properties.

Upstream product

• 54855-81-1 2-methylthioquinazolin-4(3H)-one 
• 13906-09-7 2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 13906-09-7 2-mercapto-3,4-dihydro-4-quinazolone 
• 54855-81-1 4-hydroxy-2-methylthioquinazoline 
• 28144-70-9 anthranilic acid amide 

Downstream Products

• 180959-11-9 (R)-1-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-3-(2-methylsulfanyl-quinazolin-4-ylamino)-propan-2-ol 
• 180959-10-8 (S)-1-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-3-(2-methylsulfanyl-quinazolin-4-ylamino)-propan-2-ol 
• 149847-79-0 DL 017 
• 180959-12-0 (S)-(+)-3-?(4-(2-methoxyphenyl)piperazin-1-yl)methyl-5-methylthio-2,3-dihydroimidazo[1,2-c]quinazoline 
• 180959-13-1 (R)-(-)-3-?(4-(2-methoxyphenyl)piperazin-1-yl)methyl-5-methylthio-2,3-dihydroimidazo[1,2-c]quinazoline 
• 139047-57-7 3-bromomethyl-5-methylthio-2,3-dihydroimidazo[1,2-c ]quinazoline 
• 1356922-71-8 2-methylthio-4-(4'-methylselenobenzyl)aminoquinazoline 

Relevant academic research and scientific papers

Novel quinazoline and pyrido[2,3-d]pyrimidine derivatives and their hydroselenite salts as antitumoral agents

A series of 22 quinazolines, pyrido[2,3-d]pyrimidines and their hydroselenite salts were synthesized with the aim of evaluating in vitro their cytotoxicity against PC-3 cell line and their antioxidant properties related to DPPH (1,1-diphenyl-2-picrylhydrazylradical) activity, showing some of them better profile than the respective controls. Three of these derivatives (5d, 6d and 7f) were selected in order to gain preliminary insights to establish the mechanism of action. Caspase-3 activity and cell cycle regulation studies revealed that compound 6d provoked an increase in caspase-3 level accompanied by cell cycle perturbation in a time-dependent manner.

Sulfur and selenium derivatives of quinazoline and pyrido[2,3-d]pyrimidine: Synthesis and study of their potential cytotoxic activity in vitro

The synthesis, cytotoxic activities and selectivities of 35 derivatives related to quinazoline and pyrido[2,3-d]pyrimidine are described. The synthesized compounds were screened in vitro against four tumoral cell lines - leukemia (CCRF-CEM), colon (HT-29), lung (HTB-54) and breast (MCF-7) - and two cell lines derived from non-malignant cell lines, one mammary (184B5) and one from bronchial epithelium (BEAS-2B). MCF-7 and HTB-54 were the most sensitive cell lines with GI50 values below 10 μM for eleven and ten compounds, respectively. Two compounds (2o and 3a) were identified that evoked a marked cytotoxic effect in all cell lines tested and one compound, 7h, was potent and selective against MCF-7. A preliminary study into the mechanism of the potent derivatives 2o, 3a and 7h indicated that the cytotoxic activities of these compounds might be mediated by inducing cell death without affecting cell cycle phases.

Kilogram-scale synthesis of a highly selective α1-adrenoceptor antagonist (DL-028A)

This work presents an improved eight-step process, leading to kilogram quantities of high-quality DL-028A, an antihypertensive agent. The improvements include reducing the levels of toxic reagents and the removal of dangerous processes and waste gas treatment. Moreover, specification and impurity profiles were determined.

Studies on quinazolines. 6. Asymmetric synthesis of (S)-(+)- and (R)-(-)-3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-5-methylthio-2,3- dihydroimidazo[1,2-c]quinazolines

The titled compounds have been synthesized in five steps from commercially available (R)-(+) and (S)-(-)-glycidol. The overall yield was about 29% with ee>98.5%. Copyright