149847-79-0

Basic information

• Product Name: Imidazo[1,2-c]quinazoline,2,3-dihydro-3-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-5-(methylthio)-
• Synonyms: DL 017
• CAS NO: 149847-79-0
• Molecular Formula: C23H27 N5 O S
• Molecular Weight: 421.566
• Mol File: 149847-79-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Imidazo[1,2-c]quinazoline,2,3-dihydro-3-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-5-(methylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-c]quinazoline,2,3-dihydro-3-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-5-(methylthio)-(149847-79-0)
• EPA Substance Registry System: Imidazo[1,2-c]quinazoline,2,3-dihydro-3-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-5-(methylthio)-(149847-79-0)

Safety Data

• Hazardous Substances Data: 149847-79-0(Hazardous Substances Data)

Upstream product

• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 139047-57-7 3-bromomethyl-5-methylthio-2,3-dihydroimidazo[1,2-c ]quinazoline 
• 5464-78-8 1-(2-methoxyphenyl)piperazine hydrochloride 
• 28144-70-9 anthranilic acid amide 
• 139047-56-6 4-allylamino-2-methylthioquinazolin 
• 180959-08-4 (S)-(+)-1-amino-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-2-ol 
• 58803-74-0 4-chloro-2-(methylthio)quinazoline 
• 48141-61-3 2,4-bis(methylthio)quinazoline 
• 54855-81-1 2-methylthioquinazolin-4(3H)-one 
• 13906-09-7 2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 180959-10-8 (S)-1-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-3-(2-methylsulfanyl-quinazolin-4-ylamino)-propan-2-ol 
• 180959-06-2 (R)-(+)-1-phthaloylamino-3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-2-ol 

Downstream Products

• 149847-83-6 3-<<4-(2-methoxyphenyl)piperazine-1-yl>methyl>-5-methoxy-2,3-dihydroimidazo<1,2-c>quinazoline 

Relevant articles and documents

Kilogram-scale synthesis of a highly selective α1-adrenoceptor antagonist (DL-028A)

This work presents an improved eight-step process, leading to kilogram quantities of high-quality DL-028A, an antihypertensive agent. The improvements include reducing the levels of toxic reagents and the removal of dangerous processes and waste gas treatment. Moreover, specification and impurity profiles were determined.

Studies on quinazolines. 6. Asymmetric synthesis of (S)-(+)- and (R)-(-)-3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-5-methylthio-2,3- dihydroimidazo[1,2-c]quinazolines

The titled compounds have been synthesized in five steps from commercially available (R)-(+) and (S)-(-)-glycidol. The overall yield was about 29% with ee>98.5%. Copyright