60018-14-6

Upstream product

• 108-05-4 vinyl acetate 
• 53713-43-2 6-benzyloxy-2-(2-hydroxyethyl)-2,5,7,8-tetramethylchroman 
• 7564-64-9 3-methyl-1,3,5-pentanetriol 
• 58846-72-3 (2S)-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)acetic acid methyl ester 
• 700-13-0 Trimethylhydroquinone 
• 100-39-0 benzyl bromide 
• 79907-48-5 2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-benzo[1,2-b]pyran-2-yl)ethanol 
• 443903-06-8 (S)-(+)-2-(2-acetoxyethyl)-6-benzyloxy-2,5,7,8-tetramethylchroman 

Downstream Products

• 59965-21-8 (S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ethanol p-toluenesulfonate 
• 443903-19-3 (S)-6-benzyloxy-2-(2-dimethylaminoethyl)-2,5,7,8-tetramethylchroman 
• 58846-73-4 (S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-acetaldehyde 

Relevant academic research and scientific papers

2,5,6,7,8-Pentasubstituted (S)- and (R)-[2-chroman-2-yl]ethanols as intermediates for the synthesis of α-tocopherol and its chiral analogs

In the presence of lipase from the yeast Candida cylindracea, partial acetylation of (±)-2-[6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl]ethanol with vinyl acetate gives S-(+)-acetate whose alkaline hydrolysis affords (5)-( - )-alcohol. Repeated enzymatic

Enzymatic Synthesis of (S)-2-(6-Benzyloxy-2,5,7,8-tetramethyl-2-chromanyl)ethanol, Intermediate for the Synthesis of Vitamin E

Racemic 2-(6-benzyloxy-2,5,7,8-tetramethyl-2-chromanyl)ethanol (5) was successfully resolved by employing asymmetric benzoylation and lipoprotein lipase (LPL). (S)-5 was obtained with more than 99percent e.e.

Intermediates in the synthesis of vitamin E

A synthesis of vitamin E in racemic or optically active forms from methacryolein or beta-hydroxyisobutyric acid including intermediates in this synthesis.