58861-75-9

Basic information

• Product Name: 1‐phenyl‐2‐(piperidin‐1‐yl)‐2‐thioxoethan‐1‐one
• Synonyms: 1‐phenyl‐2‐(piperidin‐1‐yl)‐2‐thioxoethan‐1‐one
• CAS NO: 58861-75-9
• Molecular Weight: 233.334
• Mol File: 58861-75-9.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1‐phenyl‐2‐(piperidin‐1‐yl)‐2‐thioxoethan‐1‐one(CAS DataBase Reference)
• NIST Chemistry Reference: 1‐phenyl‐2‐(piperidin‐1‐yl)‐2‐thioxoethan‐1‐one(58861-75-9)
• EPA Substance Registry System: 1‐phenyl‐2‐(piperidin‐1‐yl)‐2‐thioxoethan‐1‐one(58861-75-9)

Safety Data

• Hazardous Substances Data: 58861-75-9(Hazardous Substances Data)

Upstream product

• 779-52-2 1-phenyl-2-piperidin-1-yl-ethanone 
• 110-89-4 piperidine 
• 98-86-2 acetophenone 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 2461-80-5 diphenacyl sulfide 
• 70-11-1 α-bromoacetophenone 
• 614-21-1 2-nitroacetophenone 
• 4452-12-4 1-phenyl-3-(piperidin-1-yl)prop-2-en-1-one 
• 1816-88-2 2-azido-1-phenylethan-1-one 

Relevant articles and documents

Efficient Synthesis of α-Ketothioamides From α-Nitroketones, Amines or DMF and Elemental Sulfur Under Oxidant-Free Conditions

We have developed a practical, general protocol for denitration of readily available α-nitroketones with sulfur and amines to access a broad range of α-ketothioamides under mild conditions. Such a reaction proceeds under metal-, oxidant-, and catalyst-free conditions to provide synthetically useful α-ketothioamides. Furthermore, the mild reaction conditions tolerate a wide range of substrates especially for the synthesis of aliphatic α-ketothioamides which are rarely reported.

Metal-Free C-N or C-C Bond Cleavages of α-Azido Ketones: An Oxidative-Amidation Strategy for the Synthesis of α-Ketothioamides and Amides

A novel metal-free oxidative-amidation strategy for the synthesis of α-ketothioamides and amides from α-azido ketones was developed. The C-H bond thionation of α-azido ketones with elemental sulfur could form α-ketothioacyl azide, which was then nucleophilically attacked by amines, causing the cleavage of the C-N bond to afford α-ketothioamides, while amides could be formed with the release of nitrogen gas and cyano anion in the presence of PhI(OAc)2 by selective C-C bond cleavage.

Methyl ketone break-and-rebuild: A strategy for full α-heterofunctionalization of acetophenones

The Willgerodt reaction under iron-catalyzed aerobic conditions was found to be an excellent tool for full α-heterofunctionalization of acetophenones with sulfur and amines. Via this break-and rebuild strategy, a wide range of thioglyoxamides was synthesi