4452-12-4

Basic information

• Product Name: 1-Phenyl-3-piperidino-2-propene-1-one
• Synonyms: 1-(2-Benzoylvinyl)piperidine;1-Phenyl-3-(piperidin-1-yl)-2-propen-1-one-;1-Phenyl-3-piperidino-2-propene-1-one;β-(Piperidin-1-yl)acrylophenone;β-Piperidinoacrylophenone
• CAS NO: 4452-12-4
• Molecular Formula: C₁₄H₁₇NO
• Molecular Weight: 215.29
• Mol File: 4452-12-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Phenyl-3-piperidino-2-propene-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-3-piperidino-2-propene-1-one(4452-12-4)
• EPA Substance Registry System: 1-Phenyl-3-piperidino-2-propene-1-one(4452-12-4)

Safety Data

• Hazardous Substances Data: 4452-12-4(Hazardous Substances Data)

Usage

Chemical Family

Arylpiperidines

Physical Description

White to light yellow crystalline solid with a faint odor

Usage

Intermediate in the synthesis of pharmaceuticals and organic compounds

Potential Applications

Medicinal chemistry, therapeutic agent for various medical conditions

Biological and Pharmacological Effects

Not fully elucidated, requires further research for full understanding.

Upstream product

• 110-89-4 piperidine 
• 40685-20-9 (E)-3-methoxy-1-phenylprop-2-en-1-one 
• 21440-46-0 1-Phenyl-3-p-toluolsulfonyl-propen-⁽²⁾-on-⁽¹⁾ 
• 120225-40-3 trimethyl-(3-oxo-3-phenyl-propenyl)-ammonium; chloride 
• 49660-41-5 triethyl-(3-oxo-3-phenyl-propenyl)-ammonium; chloride 
• 51752-63-7 Piperidineformaldehyde diethylacetal 
• 98-86-2 acetophenone 
• 3592-47-0 Benzaldehyde-d 
• 70485-98-2 (E)-3-(diisopropylamino)-1-phenylprop-2-en-1-one 
• 100-52-7 benzaldehyde 

Downstream Products

• 62035-05-6 5-benzoyl-2-phenyl-6-piperidin-1-yl-5,6-dihydro-[1,3]thiazin-4-one 
• 62035-04-5 5-benzoyl-2-phenyl-[1,3]thiazin-4-one 
• 7632-73-7 1-phenyl-3-piperidino-2-propene-1-thione 
• 92126-72-2 6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 99482-90-3 4-phenyl-3-cyano-2(1H)-pyridinethione 
• 118947-88-9 6-Phenyl-2-selenoxo-1,2-dihydro-pyridine-3-carbonitrile 
• 99482-91-4 4-phenyl-3-cyano-2(1H)-pyridineselenone 
• 2305-87-5 4-phenylpyrimidin-2-amine 
• 99482-93-6 3-amino-2-benzoyl-4-phenylthieno<2,3-b>pyridine 
• 14377-63-0 1-(phenylglyoxylyl)piperidine 
• 58861-75-9 1‐phenyl‐2‐(piperidin‐1‐yl)‐2‐thioxoethan‐1‐one 
• 1702-14-3 ethyl 2-methyl-6-phenylnicotinate 

Relevant articles and documents

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Acetylide Ion (C22-) as a synthon to link electrophiles and nucleophiles: A simple method for enaminone synthesis

Friendly competition: A three-component reaction system composed of calcium carbide, an aryl aldehyde, and an amine gave enaminones or propargylamines (see picture) in a predictable manner through competitive pathways. The system enables the cost-efficient synthesis of a variety of enaminones from readily accessible small molecules and demonstrates the versatility of the acetylide ion, which can be used to bridge electrophiles and nucleophiles. Copyright

AMINOLYSIS OF VINYLAMMONIUM SALTS. EFFECTS OF STRUCTURE AND MEDIUM

The kinetics of the aminolysis of a series of vinylammonium salts ZCH=CHN+R3*X- were investigated in polar solvents and in water at 25 deg C.A quantitative assessment was made of the effect of the nature of the medium and the structure of activating group Z on the rate of the investigated processes.The aminolysis rate of the salts increases with increase in the donating characteristics of the solvent on account of the greater stabilization of the transition state compared with the initial state.Increase in the accepting characteristics of the medium leads to retardation of the process as a result of increase in the electrophilic solvation of the amine in the initial state.