588730-02-3

Upstream product

• 588730-01-2 N-(6-bromo-thiazolo[5,4-b]pyridine-2-yl)-benzamide 
• 98-80-6 phenylboronic acid 
• 98-88-4 benzoyl chloride 
• 588729-97-9 N-(6-bromo[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide 
• 588729-96-8 N-benzoyl-N'-(5-bromo-3-chloro-2-pyridyl)thiourea 

Relevant academic research and scientific papers

Oxidative cyclization of N-methyl- and N-benzoylpyridylthioureas. Preparation of new thiazolo[4,5-b] and [5,4-b]pyridine derivatives

Cyclization of N-methyl- and N-benzoylpyridylthioureas, prepared from the corresponding aminopyridines, has been realized using various conditions. With bromine in acetic acid or potassium ferricyanide, the cyclization occurred on the nitrogen of the pyridine ring and pyridinium salts or 1,2,4-thiadiazolo[2,3-a]pyridylidene systems were obtained. On the other hand, treatment of the thioureas with sodium methoxide in N-methylpyrrolidinone (NMP) led to formation of thiazolo[4,5-b] and [5,4-b]pyridines, which are interesting targets for biological evaluation.