58976-46-8

Usage

Uses

Used in Pharmaceutical Industry:
ALA-GLY-CYS-LYS-ASN-PHE-PHE-D-TRP-LYS-THR-PHE-THR-SER-CYS is used as a potential therapeutic agent for its possible interactions with other molecules and its role in protein structuring. The presence of specific amino acids may contribute to its efficacy in treating certain conditions or diseases.
Used in Biochemical Research:
This peptide sequence is used as a research tool in biochemical studies to understand its interactions with other molecules and its potential roles in biological processes. The sequence's composition and structure provide valuable insights into peptide function and behavior in various biological systems.
Used in Drug Development:
ALA-GLY-CYS-LYS-ASN-PHE-PHE-D-TRP-LYS-THR-PHE-THR-SER-CYS may be utilized in the development of new drugs, given its potential therapeutic applications and interactions with other molecules. Its unique sequence and properties could be harnessed to create novel pharmaceutical compounds with specific therapeutic targets or mechanisms of action.

InChI:InChI=1/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42?,43?,50-,51-,52-,53-,54-,55+,56-,57-,58-,59-,62-,63-/m0/s1

Upstream product

• 4530-20-5 BOC-glycine 
• 15761-38-3 L-N-Boc-Ala 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 18942-46-6 N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteine 
• 54613-99-9 Boc-(S)-Lys(2-Cl-Z)-OH 
• 5241-64-5 Boc-D-Trp-OH 
• 65420-40-8 (S)-2-tert-Butoxycarbonylamino-N-(9H-xanthen-9-yl)-succinamic acid 

Relevant academic research and scientific papers

Fine-tuning the π-π Aromatic interactions in peptides: Somatostatin analogues containing mesityl alanine

Going through the motions: Somatostatin analogues having greater conformational rigidity than somatostatin have been prepared by substituting Phe residues in the native sequence with mesityl alanine (Msa; see structure). The analogues show high affinity f

N-Imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function

Despite 3 decades of focused chemical, biological, structural, and clinical developments, unusual properties of somatostatin (SRIF, 1) analogues are still being uncovered. Here we report the unexpected functional properties of 1 and the octapeptide cyclo(3-14)H-Cys-Phe-Phe-Trp8-Lys-Thr-Phe-Cys-OH (somatostatin numbering; OLT-8, 9) substituted by imBzl-l- or -d-His at position 8. These analogues were tested for their binding affinity to the five human somatostatin receptors (sst1-5), as well as for their functional properties (or functionalities) in an sst3 internalization assay and in an sst3 luciferase reporter gene assay. While substitution of Trp8 in somatostatin by imBzl-l- or -d-His8 results in sst3 selectivity, substitution of Trp8 in the octapeptide 9 by imBzl-l- or -d-His8 results in loss of binding affinity for sst1,2,4,5 and a radical functional switch from agonist to antagonist.