59025-38-6

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Pyrrolidin-1-ylnicotinonitrile is used as a building block in the synthesis of various pharmaceuticals due to its versatile chemical properties and ability to form stable compounds.
Used in Agrochemical Synthesis:
2-Pyrrolidin-1-ylnicotinonitrile is used as a building block in the synthesis of various agrochemicals, contributing to the development of effective and environmentally friendly products.
Used in Antiviral Applications:
2-Pyrrolidin-1-ylnicotinonitrile is used as a potential antiviral agent, with ongoing research exploring its ability to inhibit viral replication and reduce the severity of viral infections.
Used in Anticancer Applications:
2-Pyrrolidin-1-ylnicotinonitrile is used as a potential anticancer agent, with studies investigating its ability to target and inhibit the growth of cancer cells.
Used in Corrosion Inhibition:
2-Pyrrolidin-1-ylnicotinonitrile is used as a potential corrosion inhibitor for metallic materials, with research exploring its ability to protect metals from corrosion and extend their service life.
Used in Medicinal Chemistry Research:
2-Pyrrolidin-1-ylnicotinonitrile is used as a subject of interest in medicinal chemistry research, with ongoing studies investigating its potential applications and mechanisms of action in various therapeutic areas.

Upstream product

• 123-75-1 pyrrolidine 
• 17132-78-4 Pyridine-2,3-dicarbonitrile 
• 3939-13-7 3-cyano-2-fluoropyridine 
• 20577-26-8 2-bromonicotinonitrile 

Downstream Products

• 859850-79-6 C-(2-pyrrolidin-1-yl-pyridin-3-yl)-methylamine 

Relevant academic research and scientific papers

Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the corresponding N-arylation product in an excellent yield.

Co(II)-Catalyzed Regioselective Pyridine C-H Coupling with Diazoacetates

A Co(II)-catalyzed pyridyl C-H bond carbenoid insertion with α-diazoacetates has been realized. This transformation features a highly regioselective C-C bond formation at the C3-position of pyridines, providing an efficient access to diverse α-aryl-α-pyri

P2X7 receptor antagonists and methods of use

The invention is directed to compounds that are P2X7 antagonist and have the formula (I) or (II) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug or a combination thereof, wherein R1, R2, and R3 /sub

AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE

A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R 5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

A Study of the Photochemically Induced Electron-Transfer Reactions Between Pyridinedicarbonitriles and Primary and Secondary Aliphatic Amines

A study on the photochemically induced electron-transfer from primary and secondary aliphatic amines as donors to pyridinecarbonitriles as the acceptor is reported.A comparison between the substitution positions and the spin density distributions, obtained via teoretical calculations using the 6-31+G basis set, shows some discrepancies, and forms the basis of a hypothesis on the mechanism of the reaction.