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59086-90-7

59086-90-7

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  • 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one,6-(benzoyloxy)-4-[(benzoyloxy)methyl]-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-1,1,7,9-tetramethyl-,(1aR,2S,5R,5aR,6S,8aS,9R,10aR)-

    Cas No: 59086-90-7

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  • 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one,6-(benzoyloxy)-4-[(benzoyloxy)methyl]-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-1,1,7,9-tetramethyl-,(1aR,2S,5R,5aR,6S,8aS,9R,10aR)- cas

    Cas No: 59086-90-7

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59086-90-7 Usage

Uses

Ingenol 3,20-dibenzoate is an activator of protein kinase C (PKC) and apoptotic inducer.

Check Digit Verification of cas no

The CAS Registry Mumber 59086-90-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,0,8 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 59086-90:
(7*5)+(6*9)+(5*0)+(4*8)+(3*6)+(2*9)+(1*0)=157
157 % 10 = 7
So 59086-90-7 is a valid CAS Registry Number.
InChI:InChI=1/C34H36O7/c1-19-17-33-20(2)15-25-26(32(25,3)4)24(28(33)36)16-23(18-40-30(37)21-11-7-5-8-12-21)27(35)34(33,39)29(19)41-31(38)22-13-9-6-10-14-22/h5-14,16-17,20,24-27,29,35,39H,15,18H2,1-4H3/t20-,24+,25-,26+,27-,29+,33?,34+/m1/s1

59086-90-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name INGENOL 3,20-DIBENZOATE

1.2 Other means of identification

Product number -
Other names ingenoldibenzoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:59086-90-7 SDS

59086-90-7Downstream Products

59086-90-7Relevant articles and documents

Synthesis of modified ingenol esters

Appendino, Giovanni,Tron, Gian Cesare,Cravotto, Giancarlo,Palmisano, Giovanni,Annunziata, Rita,Baj, Germano,Surico, Nicola

, p. 3413 - 3420 (2007/10/03)

Synthetic protocols for the manipulation of the polyhydroxylated southern region of ingenol (1a) were developed, and a series of isosteres of the anticancer compound ingenol 3,20-dibenzoate (1b) was prepared. The biological evaluation of these compounds showed that cytotoxicity was relatively tolerant to changes at C-20, while PKC activation was markedly affected by these modifications. These data suggest that chemical manipulation can effectively dissect cytotoxicity and tumour-promoting activity (or potential) of ingenoids, affording more optimal candidates for development, like 20-deoxy-20-fluoroingenol 3,20-dibenzoate (5b). In mild acidic medium, an unexpected vinylogous retro-pinacol rearrangement of ingenol to a tigliane derivative was observed.

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