59120-86-4Relevant academic research and scientific papers
Direct carbocyclizations of benzoic acids: Catalyst-controlled synthesis of cyclic ketones and the development of tandem aHH (acyl Heck-Heck) reactions
Miles, Kelsey C.,Le, Chi,Stambuli, James P.
, p. 11336 - 11339 (2014/10/16)
The formation of exo-methylene indanones and indenones from simple ortho-allyl benzoic acid derivatives has been developed. Selective formation of the indanone or indenone products in these reactions is controlled by choice of ancillary ligand. This new process has a low environmental footprint as the products are formed in high yields using low catalyst loadings, while the only stoichiometric chemical waste generated from the reactants in the transformation is acetic acid. The conversion of the active cyclization catalyst into the Hermman-Beller palladacycle was exploited in a one-pot tandem acyl Heck-Heck (aHH) reaction, and utilized in the synthesis of donepezil. Carboxylic acids in aHH: Simple ortho-allyl benzoic acid derivatives have been utilized in an acyl Heck (aH) reaction to selectively form indanones and indenones. The conversion of the active cyclization catalyst into the Hermman-Beller palladacycle was exploited in a one-pot tandem acyl Heck-Heck (aHH) reaction to form two sp 2-sp2 bonds of (E)-trisubstituted olefins.
Formation of dimers of some 2-substituted indan-1-one derivatives during base-mediated cross-aldol condensation
Narang, Gaurav,Jindal, Dharam Paul,Jit, Birinder,Bansal, Ranju,Potter, Brian S.,Palmer, Rex A.
, p. 258 - 264 (2007/10/03)
Unexpected dimers of some 2-substituted indan-1-one derivatives were isolated during aldol condensation of indan-1-one with various aldehydes in the presence of KOH (see Scheme). Monomeric products, usually expected from aldol condensation, further underw
