5916-10-9

Upstream product

• 186581-53-3 diazomethane 
• 77-78-1 dimethyl sulfate 
• 177949-92-7 (E)-4,4,5,5-tetramethyl-2-(3-methylbut-1-en-1-yl)-1,3,2-dioxaborolane 
• 500-99-2 3,5-dimethoxyphenol 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 65612-84-2 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(2,4-dimethoxyphenyl)propane-1,3-dione 
• 65612-86-4 2-(2,4-dimethoxyphenyl)-5,7-dimethoxy-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one 
• 1443276-25-2 2-(2,4-dimethoxyphenyl)-5-hydroxy-6-(1-hydroxy-3-methylbutyl)-7-methoxy-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one 
• 1443276-24-1 2-(2,4-dimethoxyphenyl)-5-hydroxy-7-methoxy-3-(3-methylbut-2-en-1-yl)-6-(3-methylbutanoyl)-4H-chromen-4-one 
• 1443276-21-8 1-(2,6-dihydroxy-4-methoxy-3-(3-methylbutanoyl)phenyl)-3-(2,4-dimethoxyphenyl)-2-(3-methylbut-2-en-1-yl)propane-1,3-dione 
• 1443276-19-4 2-acetyl-3,5-dimethoxy-6-(3-methylbutanoyl)phenyl 2,4-dimethoxybenzoate 
• 621-23-8 1,2,3-trimethoxybenzene 
• 1443276-18-3 1-(3-acetyl-2-hydroxy-4,6-dimethoxyphenyl)-3-methyl-1-butanone 
• 832-58-6 1-(2,4,6-trimethoxyphenyl)ethanone 

Downstream Products

• 115388-51-7 2-(2,4-dimethoxy-phenyl)-5-hydroxy-6-isopentyl-7-methoxy-3-(3-methyl-but-2-enyl)-chromen-4-one 
• 503-74-2 3-methylbutyric acid 
• 91-52-1 2,4 dimethoxybenzoic acid 
• 1443276-27-4 (E)-5-hydroxy-2-(2-hydroxy-4-methoxyphenyl)-7-methoxy-6-(3-methylbut-1-en-1-yl)-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one 
• 1443276-28-5 (E)-5-hydroxy-2-(4-hydroxy-2-methoxyphenyl)-7-methoxy-6-(3-methylbut-1-en-1-yl)-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one 
• 1443276-29-6 (E)-5-hydroxy-7-methoxy-2-(4-methoxy-2-((4-methoxybenzyl)oxy)phenyl)-6-(3-methylbut-1-en-1-yl)-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one 
• 1443276-30-9 (E)-5-hydroxy-2-(4-hydroxy-2-((4-methoxybenzyl)oxy)phenyl)-7-methoxy-6-(3-methylbut-1-en-1-yl)-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one 
• 7608-44-8 Artocarpin 
• 1443276-43-4 (E)-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-6-(3-methylbut-1-en-1-yl)-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one 

Relevant academic research and scientific papers

Formal total synthesis of artocarpin

A formal total synthesis of artocarpin was achieved via selective demethylation, iodination, followed by Suzuki-Miyaura coupling reaction of the key flavone derivative. It took only 7 steps in the overall yield of 55% starting from commercially available 3,5-dimethoxyphenol.

Total syntheses of norartocarpin and artocarpin

The total syntheses of norartocarpin and artocarpin, two biologically interesting natural flavonoids with two regioisomeric isoprenyl side chains, were achieved for the first time via a linear reaction sequence of 9 and 12 steps with the overall yields of