65612-84-2

Upstream product

• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 2150-41-6 methyl 2, 4-dimethoxybenzoate 
• 53931-00-3 2,4-dimethoxybenzoic anhydride 
• 91-52-1 2,4 dimethoxybenzoic acid 
• 500-99-2 3,5-dimethoxyphenol 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 39828-35-8 2,4-dimethoxybenzoyl chloride 

Downstream Products

• 72357-29-0 7,5,2',4'-tetramethoxyflavone 
• 65612-86-4 2-(2,4-dimethoxyphenyl)-5,7-dimethoxy-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one 
• 5916-10-9 (E)-2-(2,4-dimethoxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-1-en-1-yl)-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one 
• 520-30-9 norartocarpetin 

Relevant academic research and scientific papers

Formal total synthesis of artocarpin

A formal total synthesis of artocarpin was achieved via selective demethylation, iodination, followed by Suzuki-Miyaura coupling reaction of the key flavone derivative. It took only 7 steps in the overall yield of 55% starting from commercially available 3,5-dimethoxyphenol.

5, 7, 2 ,, 4 ,-four hydroxy-3-hydrocarbyl flavone analogs and its preparation method and application (by machine translation)

The invention discloses 5,7,2',4'-tetrahydroxy-3-alkyl flavone analog. On the basis of 5,7,2',4'-tetrahydroxy-3-geranyl (isopentene group) flavone and with the combination of the characteristics that due to the fact that alkylate medicine is extremely sensitive to malignant cells, alkylate medicine can well inhibit and eliminate activity of cancer cells, the inventor studies and prepares (+/-) 5,7,2',4'-hydroxyl (methoxyl)-3-(3,7-dimethyl octane) flavone with the flavonoid compound skeletal structure and 5,7,2',4'-hydroxyl (methoxyl)-3-(3-metryl butane) flavone with the flavonoid compound skeletal structure, conducts total synthesis on the (+/-) 5,7,2',4'-hydroxyl (methoxyl)-3-(3,7-dimethyl octane) flavone and the 5,7,2',4'-hydroxyl (methoxyl)-3-(3-metryl butane) flavone, and does in-depth study on the cervical cancer prevention effect and the hepatoma carcinoma cell activity. The in-vitro cancer cell activity inhibitory test shows that the compound can obviously inhibit cervical cancer Hela cells and liver cancer strain 7721 cells and can serve as candidate medicine for treating cervical cancer and liver cancer.

Natural product analogues Albanin A/E and its preparation method and application

The invention discloses a natural product Albanin A/E analogue. The inventor does research and prepares the natural product Albanin A/E analogue with the flavonoids compound framework structure on the basis of the natural product Albanin A and the natural product Albanin E, and complete synthesis and in-depth study of cervical cancer cell resistance activity are conducted on the natural product Albanin A/E analogue. The in-vitro cancer cell inhibition activity test shows that the compound has obvious effects on inhibiting cervical cancer Hela cells, and can be used for preparing candidate medicine for treating cervical cancer.