59178-92-6

Basic information

• Product Name: 6-[(2-methyl-1-oxoallyl)amino]hexanoic acid
• Synonyms: 6-[(2-methyl-1-oxoallyl)amino]hexanoic acid;6-[(2-Methyl-1-oxo-2-propenyl)amino]hexanoic acid;Einecs 261-644-8
• CAS NO: 59178-92-6
• Molecular Formula: C₁₀H₁₇NO₃
• Molecular Weight: 199.24688
• EINECS: 261-644-8
• Mol File: 59178-92-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 423.7°C at 760 mmHg
• Flash Point: 210°C
• Appearance: /
• Density: 1.053g/cm³
• Vapor Pressure: 2.29E-08mmHg at 25°C
• Refractive Index: 1.474
• CAS DataBase Reference: 6-[(2-methyl-1-oxoallyl)amino]hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(2-methyl-1-oxoallyl)amino]hexanoic acid(59178-92-6)
• EPA Substance Registry System: 6-[(2-methyl-1-oxoallyl)amino]hexanoic acid(59178-92-6)

Safety Data

• Hazardous Substances Data: 59178-92-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H17NO3/c1-8(2)10(14)11-7-5-3-4-6-9(12)13/h1,3-7H2,2H3,(H,11,14)(H,12,13)

Upstream product

• 760-93-0 methacryloyl anhydride 
• 60-32-2 6-aminohexanoic acid 
• 920-46-7 Methacryloyl chloride 

Downstream Products

• 2387-23-7 1,3-Dicyclohexylurea 
• 1372411-07-8 9-(N-methacryloyl-ε-aminohexanoyloxy)-3,3-diphenyl-3H-naphtho[2,1-b]pyran 
• 1372411-09-0 5-(N-methacryloyl-ε-aminohexanoyloxy)-3,3-di(4-methoxyphenyl)-3H-naphtho[2,1-b]pyran 
• 64407-57-4 N,N-dicyclohexylurea 
• 554-68-7 triethylamine hydrochloride 

Relevant articles and documents

Abiotic Mimic of Endogenous Tissue Inhibitors of Metalloproteinases: Engineering Synthetic Polymer Nanoparticles for Use as a Broad-Spectrum Metalloproteinase Inhibitor

We describe a process for engineering a synthetic polymer nanoparticle (NP) that functions as an effective, broad-spectrum metalloproteinase inhibitor. Inhibition is achieved by incorporating three functional elements in the NP: a group that interacts with the catalytic zinc ion, functionality that enhances affinity to the substrate-binding pocket, and fine-tuning of the chemical composition of the polymer to strengthen NP affinity for the enzyme surface. The approach is validated by synthesis of a NP that sequesters and inhibits the proteolytic activity of snake venom metalloproteinases from five clinically relevant species of snakes. The mechanism of action of the NP mimics that of endogenous tissue inhibitors of metalloproteinases. The strategy provides a general design principle for synthesizing abiotic polymer inhibitors of enzymes.

COMPOSITIONS AND METHODS OF MANUFACTURING STAR POLYMERS FOR LIGAND DISPLAY AND/OR DRUG DELIVERY

A star polymer of formula O[P1]-([X]-A[P2]-[Z]-[P3])n where O is a core; A is a polymer arm attached to the core; X is a linker molecule between the core and the polymer arm; Z is a linker molecule between the end of the polymer arm and P3; P1, P2 and P3 are each independently one or more pharmaceutically active compounds that act extracellularly or intracellularly, n is an integer number; [ ] denotes that the group is optional; and at least one of P1, P2 or P3 is present.

Synthesis and structures of zwitterionic polymers to induce electrostatic interaction with PDMS surface treated by air-plasma

Various zwitterionic polymers, sulfobetaine and phosphoryl choline derivatives were synthesized in order to investigate zwitterionic polymer structures toward surface modification of PDMS, where the adsorption of zwitterionic polymers on polydimethylsiloxane surface treated with air-plasma was induced by the electrostatic interaction,. The electrostatic interaction was evaluated with hydrophilicity. The results suggested that a sulfobetaine polymer with higher molecular weight, lower molecular weight distribution, and shorter alkyl chain afforded high electrostatic interaction. A sulfobetaine polymer bearing phenylazide group showed similar electrostatic interaction with the PDMS surface, and it is a promising material for surface modification ofpolydimethylsiloxane.