59193-74-7Relevant academic research and scientific papers
Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives
Jain, Vicky,Lai, Kuo-Chu,Lee, Te-Chang,Lin, Yi-Wen,Patel, Anilkumar S.,Rao, Vaikar Navakanth,Shah, Anamik,Su, Tsann-Long
, (2020/07/04)
A series of 1,2-bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine derivatives and their alkyl (ethyl and isopropyl) carbamates and 12,13-bis(hydroxymethyl)-9,14-dihydro-dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives were synthesized for antiproliferative evaluation. The preliminary antitumour studies revealed that these two types of bis(hydroxymethyl) derivatives showed significant antitumour activities and were able to inhibit the growth of various human tumour cell lines in vitro. Several of the derivatives were demonstrated to cause DNA interstrand cross-links by an alkaline agarose gel shifting assay. These conjugates were cytotoxic to a variety of cancer cell lines by inducing DNA damage, delaying cell cycle progression in the G2/M phase and triggering apoptosis. Compound 21a, dissolved in a vehicle suitable for intravenous administration, was selected for antitumour studies in animal models. We demonstrated that at a dose that did not cause body weight loss in mice, compound 21a could significantly suppress the growth of tumour xenografts of human lung cancer H460 and colorectal cancer HCT-116 cells in nude mice. Our present results confirm the antitumour activities of these conjugates.
REISSERT COMPOUND STUDIES LXIII: PREPARATION OF REISSERT COMPOUNDS USING DIETHYLALUMINIUM CYANIDE
Duarte, Frederick F.,Popp, Frank D.
, p. 723 - 726 (2007/10/02)
Reissert compounds and analogs were synthesized from the reaction of acid halide, heterocyclic base and diethylaluminium cyanide.This new method of Reissert compound synthesis gave yields comparable to other synthetic routes.
REISSERT COMPOUND STUDIES. LIII. A NEW SYNTHESIS OF REISSERT COMPOUNDS USING TRI-n-BUTYLTIN CYANIDE
Popp, Frank D.,Kant, Joydeep
, p. 2193 - 2195 (2007/10/02)
Reissert compounds were prepared by the reaction of the heterocyclic base and acyl halide with tri-n-butyltin cyanide in methylene chloride.
Reissert Compound Studies. XLV. The Phenanthridine Reissert Compound
Kant, Joydeep,Popp, Frank D.
, p. 425 - 427 (2007/10/02)
A series of phenanthridine Reissert compounds and Reissert analogs have been prepared using the trimethylsilyl cyanide method.The reactions of the conjugate base and fluoroborate salt have been studied and found, generally, to be similar to those of the i
