59263-73-9

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 127-09-3 sodium acetate 
• 78812-98-3 1-(2-acetoxy-4-methoxyphenyl)vinyl acetate 
• 506-96-7 Acetyl bromide 
• 151-10-0 1,3-Dimethoxybenzene 

Downstream Products

• 101396-11-6 1-(2-hydroxy-4-methoxyphenyl)butane-1,3-dione 
• 78812-98-3 1-(2-acetoxy-4-methoxyphenyl)vinyl acetate 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 

Relevant academic research and scientific papers

Novel chromone and xanthone derivatives: Synthesis and ROS/RNS scavenging activities

Chromones and xanthones are oxygen-containing heterocyclic compounds acknowledged by their antioxidant properties. In an effort to develop novel agents with improved activity, a series of compounds belonging to these chemical classes were prepared. Their syntheses involve the condensation of appropriate 2-methyl-4H-chromen-4-ones, obtained via Baker-Venkataraman rearrangement, with (E)-3-(3,4-dimethoxyphenyl)acrylaldehyde to provide the corresponding 2-[(1E,3E)-4-(3,4-dimethoxyphenyl)buta-1,3-dien-1-yl]-4H-chromen-4-ones. Subsequent electrocyclization and oxidation of these compounds led to the synthesis of 1-aryl-9H-xanthen-9-ones. After cleavage of the protecting groups, hydroxylated chromones and xanthones were assessed as scavenging agents against both reactive oxygen species (ROS) [superoxide radical (O2?-), hydrogen peroxide (H2O2), hypochlorous acid (HOCl), singlet oxygen (1O2), and peroxyl radical (ROO?)] and reactive nitrogen species (RNS) [nitric oxide (?NO) and peroxynitrite anion (ONOO-)]. Generally, all the tested new hydroxylated chromones and xanthones exhibited scavenger effects dependent on the concentration, with IC50 values found in the micromolar range. Some of them were shown to have improved scavenging activity when compared with previously reported analogues, allowing the inference of preliminary conclusions on the structure-activity relationship.

Photolysis of Enol Acetates and α-Bromo Derivatives of o-(Acyloxy)acetophenones

UV irradiation of enol acetates 3a-g in benzene gives mainly o-(acetoxy)acetophenones 2 and 2-methylchromones 4. Under the same conditions, the dimethyl derivatives 3h and 3i remain unaffected.The α-bromo ketone 5a gives rise to mixtures of o-(acetoxy)acetophenone (2a), the diketone 6, and/or α-acetoxy-o-hydroxyacetophenone (7), depending on the irradiation conditions.The similarities and differences between the two series of experiments, as well as their possible mechanistic implications, are discussed.