59291-72-4

Upstream product

• 34780-29-5 3-oxo-propionic acid ethyl ester 
• 698-16-8 benzohydroximoyl chloride 
• 704-18-7 2-(hydroxyimino)-2-phenylacetic acid 
• 623-47-2 propynoic acid ethyl ester 
• 932-90-1 syn-benzaldehyde oxime 
• 924-99-2 ethyl 3-(dimethylamino)acrylate 

Downstream Products

• 18718-84-8 3-phenyl-4-isoxazolecarboxylic acid 

Relevant academic research and scientific papers

Hypervalent Iodine(III) Reagent Mediated Regioselective Cycloaddition of Aldoximes with Enaminones

An efficient oxidative cycloaddition of enaminones with nitrile oxides generated in situ from respective aldoximes using hypervalent iodine reagents has been developed. Reactions of various aldoximes with enaminones in the presence of [hydroxy(tosyloxy)iodo]benzene involved the regioselective cycloaddition reaction resulting in the formation of the 3,4-disubstituted isoxazoles in moderate to good yields. Structures of several isoxazole products were confirmed by a single X-ray crystallography.

Utilization of enols of mono- and dicarbonyls compounds in 1,3-dipolar cycloaddition reactions

2-Isoxazolines were obtained from substituted enols or their ester or ether derivatives in 1,3-dipolar cycloaddition reactions with aliphatic or aromatic nitrile oxides; the effect of the type and number of substituents present at the dipolarophile's double bond on the cycloaddition reaction course - yield, regioselectivity, and possibility of the occurrence of an elimination reaction have been investigated.

Generation of nitrile oxides from oxime derivatives by the oxidation with ammonium hexanitratocerate(IV)

Aromatic and aliphatic nitrile oxides are generated by the oxidation of α-hydroxyimino carboxylic acid with ammonium hexanitratocerate(IV). They react with olefinic and acetylenic dipolarophiles to give the corresponding cycloaddition products in good yield. The oxidation of α-oxo aldoximes also affords α-oxo carbonitrile oxides.

3-Aryl-4-isothiazolecarboxylic acid and 3-aryl-4-isoxazolecarboxylic acid derivatives and their use as herbicides

Carboxylic acid derivatives having the formula STR1 have been found to be effective herbicides. They are especially effective when applied as a pre-emergent herbicide.

3-Aryl-4-isoxazolecarboxylic acids as plant growth regulants

3-Aryl-4-isothiazolecarboxylic acids as well as 3-aryl-4-isoxazolecarboxylic acids have been found to be effective plant growth regulants especially when applied to soybean plants.