59409-41-5

Usage

InChI:InChI=1/C18H36N2O3/c1-2-3-4-5-6-7-8-9-10-14-17(21)20-16(18(22)23)13-11-12-15-19/h16H,2-15,19H2,1H3,(H,20,21)(H,22,23)/t16-/m0/s1

Upstream product

• 143-07-7 lauric acid 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 112-16-3 n-dodecanoyl chloride 
• 16079-52-0 sodium salt of L-lysine 
• 56-87-1 L-lysine 
• 14511-39-8 2(S)-2-amino-6-(benzylideneamino)hexanoic acid 
• 111-82-0 methyl n-dodecanoate 
• 609819-28-5 N-2-dodecanoyl-N-6-tert-butoxycarbonyl-L-lysine 
• 2418-95-3 (S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid 

Downstream Products

• 143-07-7 lauric acid 
• 56-87-1 L-lysine 
• 14379-54-5 N^α,N^ε-bis(1-oxododecyl)-L-lysine 
• 1391999-27-1 N_α-lauroyl-N_ε-isothiocyanato-L-lysine 

Relevant academic research and scientific papers

Preparation method of epsilon-N lauroyl lysine

The invention relates to a preparation method of epsilon-N lauroyl lysine. According to the preparation method, lysine or lysine salt and lauroyl chloride are used as raw materials. The method comprises the following specific steps: dissolving lysine in methanol to obtain a lysine methanol solution, dropwise adding lauroyl chloride at a certain temperature for an amidation reaction of lysine methanol solution, and adjusting the pH value of the mixed solution until the pH value is greater than 7 and less than or equal to 11; and after the reaction is finished, adjusting the pH value of the mixed solution to 7-9, and carrying out washing with methanol and an alcohol-water mixed solution sequentially to obtain a high-purity product. Compared with the prior art, the preparation method has theadvantages that only one step is needed for synthesis, subsequent treatment steps are simple, high temperature and high pressure are not needed in the reaction, a reaction solvent can be distilled, recovered and recycled, and the obtained product has high purity and good industrial production potential.

Novel compound N-2-alkylacryl-N-6-fluorenylmethoxycarbonyl-L-lysine

The invention relates to a novel compound N-2-alkylacryl-N-6-fluorenylmethoxycarbonyl-L-lysine (abbreviated hereinafter as compound 1). The compound 1 has a structural formula shown in the description, wherein n equals 1-18, (CH2)n is linear chain preferably, and Fmoc is fluorenylmethoxycarbonyl. As a novel L-lysine derivative compound, the N-2-alkylacryl-N-6-fluorenylmethoxycarbonyl-L-lysine is applicable to the field of medicine.

Using the ionic liquid amino or N-acylated peptide dialkylsulfosuccinic N of manufacturing method

PROBLEM TO BE SOLVED: To provide a method for synthesizing N-acylamino acid or N-acylpeptide without using fatty acid chloride.SOLUTION: The method for producing N-acylamino acid or N-acylpeptide comprises a step of reacting ionic liquefied amino acid or peptide (A) with a fatty acid or ester thereof (B) under such a condition that a molar ratio of (A):(B) is 1:10 to 10:1.

METHOD FOR TREATING SKIN CANCER

A method for treating skin cancer including the steps of applying an isothiocyanate functional surfactant to an area affected by skin cancer, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

A novel acylase from Streptomyces mobaraensis that efficiently catalyzes hydrolysis/synthesis of capsaicins as well as N-acyl-L-amino acids and N-acyl-peptides

A novel enzyme that catalyzes efficient hydrolysis of capsaicin (8-methyl-N-vanillyl-6-nonenamide) was isolated from the culture broth of Streptomyces mobaraensis. The enzyme consisted of two dissimilar subunits with molecular masses of 61 and 19 KDa. The enzyme was activated and stabilized in the presence of Co2+. It showed a pH optimum of about 8 and was stable at temperatures of up to 55°C for 1 h at pH 7.8. The specific activity of the enzyme for the hydrolysis of capsaicin was 10 2-104 times higher than those for the enzymes reported to date. In an aqueous/n-hexane biphasic system, capsaicin analogues such as octanoyl, decanoyl, and lauroyl vanillylamides were synthesized from the corresponding fatty acids and vanillylamine at yields of 50% or greater. In addition, the enzyme catalyzed the deacylation of N-lauroyl-L-amino acids and N-lauroyl-L-dipeptides and the efficient synthesis of Nα-lauroyl-L-lysine, Nε-lauroyl-L-lysine, and various N-lauroyl-peptides in aqueous solution in both the absence and the presence of glycerol.

Enzymatic synthesis of N-acyl-L-amino acids in a glycerol-water system using acylase I from pig kidney

N-Medium-and long-chain acyl-L-amino acids were enzymatically synthesized from the corresponding L-amino acids and fatty acids using a reverse hydrolysis. Enzymes that are suitable for the synthetic reaction of N-acyl-L-amino acids were screened on the basis of hydrolytic activity toward N-lauroyl-L-glutamic acid as an indicator. Acylase I from pig kidney (EC 3.5.1.14) showed the highest N-acyl-L-amino acid hydrolytic activity among 57 commercially available enzymes tested. Acylase I effectively catalyzed the synthesis of N-lauroyl-L-amino acids except for N-lauroyl-L-proline and N-lauroyl-L-tyrosine in a glycerol-water system. Under the optimized reaction conditions, N-lauroyl-L-arginine and N-lauroyl-L-glutamic acid were obtained in conversions of 82 and 44%, respectively. The equilibrium constants calculated from the conversion obtained were 5.6, 15.4, 18.0, and 39.4 for the syntheses of N-lauroyl-L-glutamic acid, Nα-lauroyl-L-lysine, N-lauroyl-L-glutamine, and N-lauroyl-L-methionine, respectively. N-Acyl-L-arginines with myristic acid and palmitic acid as the fatty acid were also synthesized using acylase I.

Cosmetic composition

A composition suitable for topical application to mammalian skin and hair for inducing, maintaining or increasing hair growth comprises a hair growth promoter chosen from glutamine derivatives and salts thereof. The composition preferably also comprises an activity enhancer which may be chosen from hair growth stimulants, penetration enhancers and cationic polymers.

Cosmetic composition containing DOPA derivatives

A composition for topical application to human hair or skin contains a chemical analogue of dihydroxyphenyl alanine (DOPA). This chemical analogue can be absorbed by skin or by a hair follicle and metabolised in-vivo, thus leading to the formation of melanin in skin or to the growth of melanin-pigmented hair. Consequently the composition can give controlled skin darkening to mimic sun-induced tanning or can bring about the growth of dar hair in place of the grey or white hair.

Cosmestic composition

A composition suitable for topical application to mammalian skin and hair for inducing, maintaining or increasing hair growth comprises a hair growth promoter chosen from glutamic acid derivatives and salts thereof. The composition preferably also comprises an activity enhancer which may be chosen from hair growth stimulants, penetration enhancers and cationic polymers.

Hair growth composition containing citric acid esters

Triesters of citric acid are used for inducing, maintaining or increasing hair growth. Compositions for topical application to mammalian hair or scalp comprise an effective amount of from 1% to 99% by weight of an ester of citric acid having the structure (1): where, R1, R2 and R3 each independently represent a branched or unbranched alkyl, alkenyl, aryl, alkylaryl or arylalkyl group, each said group having from 1 to 18 carbon atoms, R4 represents -H, or a branched or unbranched saturated or unsaturated acyl, alkyl, aryl, alkylaryl or aylalkyl group having from 1 to 18 carbon atoms, in the presence of a cosmetically acceptable vehicle for the citric acid ester and in the absence of solid absorbent for the ester;, said effective amount of said ester being sufficient to increase hair growth in the rat, when said composition is applied topically thereto over a period of no more than three months, by at least 10% more than that obtainable using a control composition from which the said ester has been omitted, in accordance with the Rat Hair Growth Test.