59424-91-8Relevant articles and documents
Pd-catalyzed synthesis of 1-(hetero)aryl-2,2,2-trichloroethanols using chloral hydrate and (hetero)arylboroxines
Shimizu, Minori,Okuda, Yuta,Toyoda, Koki,Akiyama, Ryo,Shinozaki, Hiraku,Yamamoto, Tetsuya
, p. 17734 - 17739 (2021/05/29)
1-(Hetero)aryl-2,2,2-trichloroethanols are useful key intermediates for the synthesis of various bioactive compounds. Herein, we describe N-heterocyclic carbene (NHC)-coordinated cyclometallated palladium complex (CYP)-catalyzed (hetero)aryl addition of chloral hydrate using (hetero)arylboroxines, providing a new approach to 1-(hetero)aryl-2,2,2-trichloroethanols. Notably, PhS-IPent-CYP which coordinated the bulky yet flexible 2,6-di(pentan-3-yl)aniline (IPent)-based NHC showed good catalytic activities and promoted the transformation in 24-97% yields.
A Convenient, General Synthesis of α-Trichloromethyl Carbinols
Wyvratt, Jean M.,Hazen, George G.,Weinstock, Leonard M.
, p. 944 - 945 (2007/10/02)
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NOVEL SELECTIVE SYNTHESIS OF α-CHLOROMETHYL, α,α-DICHLOROMETHYL, AND α,α,α-TRICHLOROMETHYL KETONES FROM ALDEHYDE UTILIZING ELECTROREDUCTION AS KEY REACTIONS
Shono, Tatsuya,Kise, Naoki,Yamazaki, Akira,Ohmizu, Hiroshi
, p. 1609 - 1612 (2007/10/02)
A variety of α-chloromethyl, α,α-dichloromethyl, and α,α,α-trichloromethyl ketones were synthesized from aldehyde utilizing cathodic reduction as key reactions.
