59460-88-7

Upstream product

• 63536-63-0 (6R,6'R)-3,3'-dimethyl-8,8'-dioxo-7,7'-trisulfanediyldiimino-bis-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid) dimethyl ester 
• 67-56-1 methanol 
• 701-99-5 Phenoxyacetyl chloride 
• 84819-56-7 4-Methoxy-1-[N-((6R,7R)-2-methoxycarbonyl-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-yl)-2-phenoxy-acetimidoyloxy]-pyridinium 
• 10209-06-0 (6R,7R)-methyl 3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 84819-52-3 (6R,7R)-7-[1-Chloro-2-phenoxy-eth-(Z)-ylideneamino]-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester 
• 61112-54-7 (6R)-7c-methoxy-7t-(1-methoxy-2-phenoxy-ethylideneamino)-3-methyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

7α-METHOXYLATION OF CEPHALOSPORINS

A method for 7α-methoxylation of cephalosporins is described.Treatment of the imidoyl chlorides of cephalosporins (2) with 4-methoxypyridine N-oxide afforded (4-pyrido-1-yl)oxyimino compounds (3), which were transformed to 7α-methoxycephalosporins (4) via thermal 1,4-elimination followed by addition of methanol.

A NEW SYNTHETIC METHOD FOR 7α-METHOXYCEPHALOSPORINS

A new synthetic route for 7α-methoxy-7β-acylaminocephalosporins is described.