10209-06-0Relevant academic research and scientific papers
Reactions of cephalosporin sulfones 3. Synthesis of 2- phenylhydrazonocephem-sulfones. A new potential entry to 2-aminocephems [1]
Gunda, Tamas E.,Batta, Gyula
, p. 183 - 186 (2006)
Reaction of cephem sulfones 1a-e with aryldiazonium salts gives the 2-azo compounds which immediately rearrange into the corresponding 2-hydrazono derivatives 2a-e.
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis
Gold, Ben,Smith, Robert,Nguyen, Quyen,Roberts, Julia,Ling, Yan,Lopez Quezada, Landys,Somersan, Selin,Warrier, Thulasi,Little, David,Pingle, Maneesh,Zhang, David,Ballinger, Elaine,Zimmerman, Matthew,Dartois, Véronique,Hanson, Paul,Mitscher, Lester A.,Porubsky, Patrick,Rogers, Steven,Schoenen, Frank J.,Nathan, Carl,Aubé, Jeffrey
, p. 6027 - 6044 (2016/07/26)
We report two series of novel cephalosporins that are bactericidal to Mycobacterium tuberculosis alone of the pathogens tested, which only kill M. tuberculosis when its replication is halted by conditions resembling those believed to pertain in the host, and whose bactericidal activity is not dependent upon or enhanced by clavulanate, a β-lactamase inhibitor. The two classes of cephalosporins bear an ester or alternatively an oxadiazole isostere at C-2 of the cephalosporin ring system, a position that is almost exclusively a carboxylic acid in clinically used agents in the class. Representatives of the series kill M. tuberculosis within macrophages without toxicity to the macrophages or other mammalian cells.
A New Dihydrothiazine Ring Closure for the Preparation of 3-Methylcephalosporins from Azetidinone Disulfides at 5-10 deg
Davis, Michael,Wu, Wen-Yang
, p. 1519 - 1526 (2007/10/02)
p-Nitrobenzyl (2 R, 3 R)-2-(benzothiazol-2'-yldithio)-α-isopropenyl-4-oxo-3-phenoxyacetylamino-azetidine-1-acetate (3a), readily prepared from penicillin V, is smoothly cyclized by ammonium acetate in a dimethyl sulfoxide/tetrahydrofuran mixture at 5-10 deg to the ceph-3-em ester (2a) in high yield.Other ethers (3b-d), but not the free acid (3e), behave in a similar way.The ceph-3-em esters can be readily de-esterified to the free acid (2e).
Preparation of 3-alkyl-3-cephem-4-carboxylic acid compounds from dithio isopropenyl azetidine carboxylic compounds
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, (2008/06/13)
A new process for preparing 3-alkyl-3-cephem-4-carboxylic acids of the general formula: STR1 wherein R1 is amino or a substituted amino, R2 is carboxy or a protected carboxy and R3 is a lower alkyl, and New intermediates o
