59484-42-3

Basic information

• Product Name: 2,5-DIPHENYL-1,3-THIAZOL-4-OL
• Synonyms: 2,5-DIPHENYL-1,3-THIAZOL-4-OL;2,5-Diphenyl-4-hydroxy-1,3-thiazole
• CAS NO: 59484-42-3
• Molecular Formula: C₁₅H₁₁NOS
• Molecular Weight: 253.32
• Mol File: 59484-42-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 210-212°C
• Boiling Point: 442.4°C at 760 mmHg
• Flash Point: 221.4°C
• Appearance: /
• Density: 1.259g/cm³
• Vapor Pressure: 1.93E-08mmHg at 25°C
• Refractive Index: 1.654
• PKA: 8.29±0.20(Predicted)
• CAS DataBase Reference: 2,5-DIPHENYL-1,3-THIAZOL-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIPHENYL-1,3-THIAZOL-4-OL(59484-42-3)
• EPA Substance Registry System: 2,5-DIPHENYL-1,3-THIAZOL-4-OL(59484-42-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 59484-42-3(Hazardous Substances Data)

Usage

General Description

2,5-DIPHENYL-1,3-THIAZOL-4-OL is a chemical compound with the molecular formula C15H11NOS. It is a thiazole derivative, which is a heterocyclic compound containing a five-membered ring with three carbon atoms, one sulfur atom, and one nitrogen atom. 2,5-DIPHENYL-1,3-THIAZOL-4-OL is commonly used in organic synthesis and pharmaceutical research. It has been investigated for its potential biological activities, including its antimicrobial and antioxidant properties. Additionally, it has been studied for its potential use as a building block in the development of new drugs and agrochemicals. Overall, 2,5-DIPHENYL-1,3-THIAZOL-4-OL is a versatile compound with various potential applications in the field of chemistry and medicinal research.

InChI:InChI=1/C15H11NOS/c17-14-13(11-7-3-1-4-8-11)18-15(16-14)12-9-5-2-6-10-12/h1-10,17H

Upstream product

• 33512-02-6 3-phenyl-2,2-oxiranedicarbonitrile 
• 2227-79-4 benzenecarbothioamide 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 19078-72-9 bromo(phenyl)acetyl chloride 
• 2835-06-5 phenylglycin 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 

Downstream Products

• 131786-91-9 2,5-diphenyl-4-<(ethyloxysuccinyl)oxy>thiazole 
• 65752-44-5 2,5-diphenyl-4-acetoxythiazole 
• 131786-89-5 2,5-diphenyl-4-(hexanoyloxy)thiazole 
• 133833-99-5 2,5-diphenyl-4-<(dimethylphosphono)oxy>thiazole 
• 20851-13-2 dimethyl 2,5-diphenylthiophene-3,4-dicarboxylate 
• 131786-90-8 2,5-diphenyl-4-(trimethylacetoxy)thiazole 
• 133833-98-4 2,5-diphenyl-4-methoxythiazole 

Relevant articles and documents

Bromination of α-Diazo Phenylacetate Derivatives Using Cobalt(II) Bromide

A method for the bromination of α-diazo phenylacetate derivatives using cobalt(II) bromide is described. This bromination reaction features a short reaction time, broad substrate scope, operational simplicity, acid-free conditions, and gram-scalability. (Figure presented.).

Easily assembled, modular N,O-chelating ligands for Ta(V) complexation: A comparative study of ligand effects in hydroaminoalkylation with N-methylaniline and 4-methoxy-N-methylaniline

The influence of structurally related N,O-chelating ligands with additional heteroatoms (N, O, P, S) on the reactivity of in situ generated tantalum complexes for the hydroaminoalkylation of amines has been explored. Reactivity was probed by evaluating the catalytic ability of these N,O-chelating systems with N-methylaniline and 4-methoxy-N-methylaniline substrates. Enhanced reactivity is observed with amide proligands bearing an ortho-methoxyphenyl group on the nitrogen. 4-Methoxy-N-methylaniline is found to be more prone to undergo C-H functionalization via hydroaminoalkylation than N-methylaniline. The use of the related substrate 2-methoxy-N-methylaniline is not tolerated, and instead C(sp3)-O bond cleavage was observed.

4-Hydroxythiazole Inhibitors of 5-Lipoxygenase

4-Hydroxythiazoles have been identified as potent inhibitors of 5-lipoxygenase in vitro exhibiting IC50's of less than 1 μM.An investigation of structure-activity relationships showed that the most potent inhibitors of this series are the 5-phenyl derivatives.The corresponding thiazolidin-4-one analogues were found to be relatively inactive.The 4-hydroxythiazoles were active inhibitors against 5-lipoxygenase in both intact rat polymorphonuclear leukocytes and human whole blood.The compounds were also selective inhibitors of 5-lipoxygenase, displaying only weak activity against other related enzymes, cyclooxygenase and 12- and 15-lipoxygenase.