595576-44-6

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 6-phenoxy-, methyl ester
• CAS NO: 595576-44-6
• Molecular Formula: C13H11NO3
• Molecular Weight: 229.235
• Mol File: 595576-44-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 6-phenoxy-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 6-phenoxy-, methyl ester(595576-44-6)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 6-phenoxy-, methyl ester(595576-44-6)

Safety Data

• Hazardous Substances Data: 595576-44-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 51362-51-7 6-phenoxynicotinoyl chloride 
• 51362-38-0 6-phenoxynicotinic acid 
• 73781-91-6 6-Chloronicotinic acid methyl ester 
• 108-95-2 phenol 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 66171-50-4 6-oxo-1,6-dihydropyridin-3-carboxylic acid methyl ester 

Downstream Products

• 1436378-76-5 N-{(1S)-1-[[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl]-2-methylpropyl}-5-phenoxypyridine-2-carboxamide 
• 51362-38-0 6-phenoxynicotinic acid 
• 101990-68-5 (6-phenoxy-pyridin-3-yl)-methanol 
• 910400-48-5 C₁₃H₁₄N₂O 

Relevant articles and documents

Substituent Effects of 2-Pyridones on Selective O-Arylation with Diaryliodonium Salts: Synthesis of 2-Aryloxypyridines under Transition-Metal-Free Conditions

An efficient transition-metal-free strategy to synthesize 2-aryloxypyridine derivatives has been developed by a selective O-arylation of 2-pyridones with diaryliodonium salts. The reaction was compatible with a series of functional groups for 2-pyridones and diaryliodonium salts such as halides, nitro, cyano, and ester groups. The substituents at the C6-position of 2-pyridones favored O-arylation products because of steric hindrance. The reaction was easily performed on a gram-scale and 6-chloro-2-pyridone was a good precursor to access various unsubstituted 2-aryloxypyridines by dehalogenation. A P2Y 1 lead compound analogue could be prepared in good yield over two steps.

1-substituted 4-arylpiperazine as kappa opioid receptor antagonists

Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.

1-SUBSTITUTED 4-ARYLPIPERAZINE AS KAPPA OPIOID RECEPTOR ANTAGONISTS

Provided are compounds represented by the formula: where R, Y3, R1,R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.