59562-71-9

Upstream product

• 59562-70-8 1-benzyl 6-ethyl 3-oxohexanedioate 
• 123-54-6 acetylacetone 
• 100-51-6 benzyl alcohol 
• 7149-59-9 diethyl 3-oxoadipate 

Downstream Products

• 50622-64-5 benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methylpyrrole-2-carboxylate 
• 79491-15-9 benzyl 4'-acetyl-3,3'-di(2-methoxycarbonylethyl)-4,5'-dimethyl-2,2'-dipyrrylmethane-5-carboxylate 
• 55305-15-2 3,3'-bis-(2-methoxycarbonyl-ethyl)-4,4'-bis-methoxycarbonylmethyl-1H,1'H-5,5'-methanediyl-bis-pyrrole-2-carboxylic acid dibenzyl ester 
• 70988-57-7 benzyl 5'-t.butyloxycarbonyl-4,3'-di(2-methoxycarbonylethyl)-3,4'-bismethoxycarbonylmethyl-2,2'-methylenedipyrrole-5-carboxylate 
• 102613-65-0 tert-butyl 3,3'-bis<β-(methoxycarbonyl)ethyl>-4,4'--5'-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate 
• 84315-30-0 t-butyl 5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrole-2-carboxylat 
• 72423-57-5 5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3methoxycarbonylmethylpyrrole-2-carboxylic acid 
• 524952-24-7 5-formyl-3-(2-methoxycarbonyl-ethyl)-4-(1-methoxycarbonyl-ethyl)-1H-pyrrole-2-carboxylic acid benzyl ester 
• 524952-21-4 4-(1-acetoxy-ethyl)-3-(2-ethoxycarbonyl-ethyl)-5-methyl-1H-pyrrole-2-carboxylic acid benzyl ester 
• 524952-23-6 3-(2-methoxycarbonyl-ethyl)-4-(1-methoxycarbonyl-ethyl)-5-methyl-1H-pyrrole-2-carboxylic acid benzyl ester 
• 524952-22-5 4-(cyano-methyl-methyl)-3-(2-ethoxycarbonyl-ethyl)-5-methyl-1H-pyrrole-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase

Two analogues of porphobilinogen, the 6-methyl and 6,11-ethano derivatives, have been made by a new synthetic route and the 6-methyl analogue has proved to be the most potent inhibitor of hydroxymethylbilane synthase yet reported (Ki = 3 μM).

Biosynthesis of Porphyrins and Related Macrocycles. Part 17. Chemical and Enzymic Transformation of Isomeric Aminomethylbilanes into Uroporphyrinogens: Proof that Unrearranged Bilane is the Preferred Enzymic Substrate and Detection of a Transient Intermed

Six isomeric aminomethylbilanes have been built by unambiguous synthesis.One bilane has the unrearranged structure corresponding to straightforward head-to-tail assembly of four units of porphobilinogen; the other five bilanes have one or more of the pyrr