59591-73-0

Basic information

• Product Name: 1H-INDAZOLE-3-YLPHENYL METHANONE
• Synonyms: 1H-INDAZOLE-3-YLPHENYL METHANONE
• CAS NO: 59591-73-0
• Molecular Formula: C₁₄H₁₀N₂O
• Molecular Weight: 222.242
• Mol File: 59591-73-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 188-189 °C
• Boiling Point: 433.9°Cat760mmHg
• Flash Point: 217°C
• Appearance: /
• Density: 1.283g/cm³
• Vapor Pressure: 9.88E-08mmHg at 25°C
• Refractive Index: 1.692
• PKA: 12.10±0.40(Predicted)
• CAS DataBase Reference: 1H-INDAZOLE-3-YLPHENYL METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDAZOLE-3-YLPHENYL METHANONE(59591-73-0)
• EPA Substance Registry System: 1H-INDAZOLE-3-YLPHENYL METHANONE(59591-73-0)

Safety Data

• Hazardous Substances Data: 59591-73-0(Hazardous Substances Data)

Usage

Belongs to indazoles family

Heterocyclic aromatic compounds 1H-INDAZOLE-3-YLPHENYL METHANONE is a member of the indazoles, which are a group of heterocyclic (containing atoms with non-carbon bonds) aromatic compounds known for their stability and aromaticity.

Usage in organic synthesis

Development of pharmaceutical drugs and bioactive molecules This chemical compound is commonly used in the field of organic synthesis for creating pharmaceutical drugs and other molecules with biological activity, making it a valuable component in drug development.

Importance as a building block

Creation of various organic compounds The properties and potential applications of 1H-Indazole-3-ylphenyl methanone make it an essential building block in the synthesis of a wide range of organic compounds, facilitating the development of new chemical entities.

Value in synthesis

Synthesis of novel chemical compounds with therapeutic or industrial applications The structure and reactivity of 1H-INDAZOLE-3-YLPHENYL METHANONE make it a useful tool for creating new chemical compounds with potential applications in therapeutics or various industries.

InChI:InChI=1/C14H10N2O/c17-14(10-6-2-1-3-7-10)13-11-8-4-5-9-12(11)15-16-13/h1-9H,(H,15,16)

Upstream product

• 50264-88-5 indazole-3-carbonitrile 
• 351457-12-0 1H-indazole-3-carboxylic acid methoxy(methyl)amide 
• 100-58-3 phenylmagnesium bromide 
• 91-56-5 indole-2,3-dione 
• 1552279-74-9 phenyl(2-(piperidin-1-yl)-2H-indazol-3-yl)methanone 
• 1262057-09-9 1-(2-iodophenyl)-2-(piperidin-1-yl)diazene 
• 615-43-0 2-iodophenylamine 
• 1207666-88-3 C₁₄H₉N₂⁽¹⁺⁾*HO₄S^(1-) 
• 4498-67-3 1H-Indazole-3-carboxylic acid 
• 887577-66-4 tert-butyl 3-{[methoxy(methyl)amino]carbonyl}-1H-indazole-1-carboxylate 
• 591-51-5 phenyllithium 
• 108-86-1 bromobenzene 
• 40598-94-5 3-bromo-1H-indazole 
• 98-88-4 benzoyl chloride 

Downstream Products

• 33100-54-8 (1H-indazol-3-yl)phenylmethanol 

Relevant articles and documents

BICYCLIC HETEROARYL INDOLE ANALOGUES USEFUL AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X, X1, M, R2, R3, R4, R5, m, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, neurodegenerative diseases and cancer.

Silver-catalyzed [3+2]-cycloaddition of benzynes with diazocarbonyl species via a postulated (1H-indazol-1-yl)silver intermediate

We reported a new synthesis of 2-aryl-2H-indazoles via a silver-catalyzed [3+2]-cycloaddition of benzynes with diazocarbonyl reagents. We postulate that this transformation involves the generation of (1H-indazol-1-yl)silver to activate a subsequent arylation with the second benzyne.

Design and synthesis of a new indazole library: direct conversion of?N-methoxy-N-methylamides (Weinreb amides) to 3-keto and 3-formylindazoles

Nucleophilic addition of Grignard or lithiated reagents on the new Weinreb amides 3 and 4 afforded efficiently the corresponding ketones and allowed the design and synthesis of a new indazole library. These 3-ketoindazoles were obtained by a direct and or