59591-73-0

Usage

Belongs to indazoles family

Heterocyclic aromatic compounds 1H-INDAZOLE-3-YLPHENYL METHANONE is a member of the indazoles, which are a group of heterocyclic (containing atoms with non-carbon bonds) aromatic compounds known for their stability and aromaticity.

Usage in organic synthesis

Development of pharmaceutical drugs and bioactive molecules This chemical compound is commonly used in the field of organic synthesis for creating pharmaceutical drugs and other molecules with biological activity, making it a valuable component in drug development.

Importance as a building block

Creation of various organic compounds The properties and potential applications of 1H-Indazole-3-ylphenyl methanone make it an essential building block in the synthesis of a wide range of organic compounds, facilitating the development of new chemical entities.

Value in synthesis

Synthesis of novel chemical compounds with therapeutic or industrial applications The structure and reactivity of 1H-INDAZOLE-3-YLPHENYL METHANONE make it a useful tool for creating new chemical compounds with potential applications in therapeutics or various industries.

InChI:InChI=1/C14H10N2O/c17-14(10-6-2-1-3-7-10)13-11-8-4-5-9-12(11)15-16-13/h1-9H,(H,15,16)

Upstream product

• 50264-88-5 indazole-3-carbonitrile 
• 40598-94-5 3-bromo-1H-indazole 
• 98-88-4 benzoyl chloride 
• 1207666-88-3 C₁₄H₉N₂⁽¹⁺⁾*HO₄S^(1-) 
• 3282-32-4 2-diazo-acetophenone 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 615-43-0 2-iodophenylamine 
• 1262057-09-9 1-(2-iodophenyl)-2-(piperidin-1-yl)diazene 
• 1552279-74-9 phenyl(2-(piperidin-1-yl)-2H-indazol-3-yl)methanone 
• 351457-12-0 1H-indazole-3-carboxylic acid methoxy(methyl)amide 
• 100-58-3 phenylmagnesium bromide 
• 91-56-5 indole-2,3-dione 
• 1262057-02-2 (E)-1-((2-(phenylethynyl)phenyl)diazenyl)piperidine 
• 4498-67-3 1H-Indazole-3-carboxylic acid 

Downstream Products

• 33100-54-8 (1H-indazol-3-yl)phenylmethanol 

Relevant academic research and scientific papers

BICYCLIC HETEROARYL INDOLE ANALOGUES USEFUL AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X, X1, M, R2, R3, R4, R5, m, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, neurodegenerative diseases and cancer.

Selective synthesis of indazoles and indoles via triazene-alkyne cyclization switched by different metals

We described two orthogonal heterocycle syntheses, where an arene bearing both an alkyne and a triazene functionality underwent two distinct cyclization pathways mediated by different transition metals. Starting from the same substrates, a synthesis of 2H

Silver-catalyzed [3+2]-cycloaddition of benzynes with diazocarbonyl species via a postulated (1H-indazol-1-yl)silver intermediate

We reported a new synthesis of 2-aryl-2H-indazoles via a silver-catalyzed [3+2]-cycloaddition of benzynes with diazocarbonyl reagents. We postulate that this transformation involves the generation of (1H-indazol-1-yl)silver to activate a subsequent arylation with the second benzyne.

The effect of substrate structure on the direction of cyclization of ortho-alkynylbenzene diazonium salts

The cyclization of ortho-(arylethynyl)benzene diazonium salts (the Richter reaction) is studied. A reaction mechanism, which differs radically from that reported earlier is proposed and substantiated by experimental data and quantum-chemical calculations.

Design and synthesis of a new indazole library: direct conversion of?N-methoxy-N-methylamides (Weinreb amides) to 3-keto and 3-formylindazoles

Nucleophilic addition of Grignard or lithiated reagents on the new Weinreb amides 3 and 4 afforded efficiently the corresponding ketones and allowed the design and synthesis of a new indazole library. These 3-ketoindazoles were obtained by a direct and or

A novel synthesis of 3-substituted indazole derivatives

The dianion prepared from 3-bromo-1H-indazole and alkyllithium bases reacts with a variety of electrophiles to give the corresponding 3-monosubstituted 1H-indazole derivatives in moderate yields. This procedure is more general and shorter than earlier methods.