59623-12-0

Usage

Uses

Used in Pharmaceutical Industry:
3-(4'-Methoxyphenyl)propyl chloride is used as an intermediate for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs and medications, contributing to advancements in healthcare and medicine.
Used in Agricultural Chemical Industry:
In the agricultural sector, 3-(4'-Methoxyphenyl)propyl chloride is utilized as an intermediate in the production of agricultural chemicals. Its involvement in the synthesis of these chemicals helps improve crop protection, yield, and overall agricultural productivity.
Used in Organic Synthesis for Industrial Applications:
3-(4'-Methoxyphenyl)propyl chloride is employed as a versatile building block in the synthesis of various organic compounds for industrial use. Its unique properties make it suitable for the development of new materials and compounds that can be applied in a wide range of industries, from chemical manufacturing to material science.
Used in the Synthesis of Potential Drug Candidates:
Due to its chemical versatility, 3-(4'-Methoxyphenyl)propyl chloride is used in the synthesis of potential drug candidates. Its ability to form a variety of chemical structures makes it a valuable component in the development of new therapeutic agents, contributing to the discovery of innovative treatments for various diseases and medical conditions.

InChI:InChI=1/C10H13ClO/c1-12-10-6-4-9(5-7-10)3-2-8-11/h4-7H,2-3,8H2,1H3

Upstream product

• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 
• 84648-36-2 C₁₈H₁₇ClO₅ 
• 115878-50-7 1-chloro-3-(4-methoxyphenyl)propyl phenyl sulfoxide 
• 501-36-0 (E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol 
• 22255-22-7 3,5,4'-trimethoxy-trans-stilbene 
• 24393-56-4 ethyl p-methoxycinnamate 
• 123-11-5 4-methoxy-benzaldehyde 
• 24393-56-4 ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate 
• 22767-72-2 ethyl 3-(4-methoxyphenyl)propanoate 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 

Downstream Products

• 859316-30-6 1-[3-(4-methoxy-phenyl)-propyl]-2-oxo-cyclopentanecarboxylic acid ethyl ester 
• 134266-07-2 10-[3-(4-Methoxy-phenyl)-propyl]-10H-phenothiazine 
• 134266-16-3 5-[3-(4-Methoxy-phenyl)-propyl]-10,11-dihydro-5H-dibenzo[b,f]azepine 
• 134266-13-0 10-[3-(4-Methoxy-phenyl)-propyl]-2-trifluoromethyl-10H-phenothiazine 
• 10415-00-6 [2-(2-Methoxy-phenoxy)-ethyl]-[3-(4-methoxy-phenyl)-propyl]-amine 
• 316173-58-7 3-(4-methoxyphenyl)propyl hydrazine hydrochloride 
• 316173-62-3 7-[3-(3,4-dimethoxy)-phenylpropyl]-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine 
• 316173-63-4 5-amino-1-[3-(4-methoxy)phenylpropyl]-4-[3-(2-furyl)-1,2,4-triazol-5-yl]pyrazole 
• 1026405-82-2 furan-2-carboxylic acid {4-imino-1-[3-(4-methoxy-phenyl)-propyl]-1,4-dihydro-pyrazolo[3,4-d]pyrimidin-5-yl}-amide 
• 855909-14-7 2-[3-(4-methoxy-phenyl)-propyl]-adipic acid 
• 83986-67-8 1-(methylamino)-3-(p-methoxyphenyl)propane 

Relevant academic research and scientific papers

Site-Selective Alkoxylation of Benzylic C?H Bonds by Photoredox Catalysis

Methods that enable the direct C?H alkoxylation of complex organic molecules are significantly underdeveloped, particularly in comparison to analogous strategies for C?N and C?C bond formation. In particular, almost all methods for the incorporation of alcohols by C?H oxidation require the use of the alcohol component as a solvent or co-solvent. This condition limits the practical scope of these reactions to simple, inexpensive alcohols. Reported here is a photocatalytic protocol for the functionalization of benzylic C?H bonds with a wide range of oxygen nucleophiles. This strategy merges the photoredox activation of arenes with copper(II)-mediated oxidation of the resulting benzylic radicals, which enables the introduction of benzylic C?O bonds with high site selectivity, chemoselectivity, and functional-group tolerance using only two equivalents of the alcohol coupling partner. This method enables the late-stage introduction of complex alkoxy groups into bioactive molecules, providing a practical new tool with potential applications in synthesis and medicinal chemistry.

Formononetin derivatives and preparation methods and medical application thereof

The invention relates to the field of pharmaceutical chemistry, and relates to formononetin derivatives and preparation methods and medical application thereof, in particular to formononetin derivatives with the general formula as shown in (I), preparation methods thereof, pharmaceutical compositions containing the compounds and medical application of the derivatives and the pharmaceutical compositions, particularly, application of the derivatives and the pharmaceutical compositions serving as drugs for preventing or treating hyperlipidaemia or obesity or type-II diabetes. Please see the formula in the description.

Trichloroisocynuric acid/DMF as efficient reagent for chlorodehydration of alcohols under conventional and ultrasonic conditions

A new and efficient method for the chlorodehydration of alcohols utilizing TCCA/DMF is described. Various alcohols can be converted smoothly into their corresponding alkyl chlorides in high yields under mild conditions with short reaction times. Taylor & Francis Group, LLC.

Pivaloyl chloride/DMF: a new reagent for conversion of alcohols to chlorides

An efficient procedure for conversion of alcohols into the corresponding chlorides is described. Pivaloyl chloride/DMF complex is employed as a mild and inexpensive reagent. A possible reaction mechanism is proposed.

Generation of magnesium carbenoids from 1-chloroalkyl phenyl sulfoxides with a Grignard reagent and applications to alkylation and olefin synthesis

Treatment of 1-chloroalkyl phenyl sulfoxides with a Grignard reagent at low temperature gave magnesium carbenoids in quantitative yields. The generated magnesium carbenoids were found to be stable at lower than -60°C for long periods of time and are reactive with Grignard reagents to give alkylated products. The reaction of the generated magnesium carbenoids with various kinds of lithium α-sulfonyl carbanions gave olefins with carbon-carbon bond-formation in good to high yields. This method offers a good way for the preparation of olefins. The scope and limitations of the above-mentioned reactions are described.

Stable isotope labeling pattern of resveratrol and related natural stilbenes.

The stable isotope characterization of resveratrol 1 from Polygonum cuspidatum and of related natural stilbenes 11 and 12 obtained by hydrolysis of the corresponding glucosides 2 and 3 from Rheum is reported. The C(6)-C(2)-C(6) framework of suitably protected derivatives of 1, 2, and 3 has been degraded with ozone to the C(6)-C(1) aldehydes 4, 5, 9, and 10, retaining all hydrogen atoms of the precursors. The natural and synthetic derivatives are characterized and distinguished by natural abundance deuterium nuclear magnetic resonance studies. In the case of anisaldehyde 4 the two series show, as expected, the characteristic difference of the aromatic labeling. The formyl deuterium contents of 4 and 5 from resveratrol are remarkably different, seemingly reflecting the different enrichments existing between positions 3 and 2, respectively, of the phenylpropanoid precursor. The positional delta(18)O values of the extractive materials 1-3 were also determined. In this instance a selective deoxygenation procedure was adopted, leading from 1 to the products 6, 7, and 8. The delta(18)O values of the latter compounds reveal, respectively, those at position 4' and positions 3 and 5 of 1. Similarly, the phenolic products 11 and 12 were converted into 13 and 14. From the delta(18)O values of the single components it is possible to design a detailed map of the oxygen fractionations which characterizes the stilbenes 1-3. In particular, the oxygen present at position 4' of the phenylpropanoid moiety of 1-3 shows delta(18)O values of +11.5, +1.8, and +6.7 per thousand, respectively. Moreover, the phenolic oxygen atom at position 3' of rhapontin 3 shows a value of +11.7 per thousand. The data are compared with those previously obtained on structurally related compounds. These results show the utility of simple chemical degradations in the stable isotope characterization of structurally complex food components.

Structure of ω-Arylalkyl Radicals: A 13C CIDNP Investigation

Thermolysis of a series of ω-arylalkanoyl m-chlorobenzoyl (and acetyl) peroxides at ca. 100 deg C in cyclohexanone and in hexachloroacetone was studied by using 13C chemically induced dynamic nuclear polarization.Analysis of the observed 13C polarizations indicate that all the three radicals (β-arylethyl, γ-arylpropyl and δ-arylbutyl) have open-chain structures with no evidence for aryl participation resulting in spirocycloalkylcyclohexadienyl radicals.