7576-16-1

Upstream product

• 102080-95-5 (R)-4-(formyl-methyl-amino)-2,2-diphenyl-valeronitrile 
• 125-79-1 (R,S)-2,2-diphenyl-4-dimethylaminopentanenitrile 
• 86-29-3 Diphenylacetonitrile 
• 133814-25-2 (R)-2-(dimethylamino)propane-1-ol 
• 157431-09-9 Ν,Ν-dimethyl D-alanine 
• 98069-31-9 (R)-(β-chloro-isopropyl)-methyl-formamide 
• 101792-63-6 (R)-4-formylamino-2,2-diphenyl-valeronitrile 

Downstream Products

• 125-58-6 levomethadone 
• 118413-50-6 (R)-recipavrin 
• 47110-23-6 (R)-4-dimethylamino-2,2-diphenyl-valeraldehyde 
• 60-46-8 (R)-4-dimethylamino-2,2-diphenyl-valeric acid amide 
• 5348-94-7 (R)-4-dimethylamino-2,2-diphenyl-valeric acid 
• 110050-37-8 (R)-4-dimethylamino-2,2-diphenyl-valeric acid ethyl ester 
• 106293-47-4 (R)-(+)-4-(N-carbomethoxy-N-methyl)-2,2-diphenylvaleronitrile 
• 5967-73-7 (R)-methadone hydrochloride 
• 31161-17-8 (R)-(+)-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium perchlorate 
• 106294-01-3 (R)-(-)-2-imino-1,5-dimethyl-3,3-diphenylpyrrolidine 
• 87246-92-2 (R)-(-)-1,5-dimethyl-3,3-diphenyl-2-pyrrolidone 

Relevant academic research and scientific papers

SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE OR DEXTROMETHADONE HYDROCHLORIDE AND METHODS FOR USE THEREOF

Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations

(R)- and (S)-Methadones and levo-α-acetylmethadol (LAAM) have been synthesised starting from lipase-catalysed acylation of dimethylaminopropan-2-ol. An approach to the synthesis of (R)-bufuralol is also presented.