59698-18-9Relevant articles and documents
Cyclopropane ring formation by an SmI2 mediated cyclisation of ??-halo-?±,?2-unsaturated esters
David, Herveì?,Afonso, Carlos,Bonin, Martine,Doisneau, Gilles,Guillerez, Marie-George,Guibeì?, Francì§ois
, p. 8557 - 8561 (1999)
??-Iodo- and ??-bromo-?±,?2-unsaturated esters with various substituents at the ?2- and ?3-positions readily cyclise to cyclopropane compounds in the presence of samarium diiodide and a proton source.
THERAPEUTIC COMPOUNDS AND USES THEREOF
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Paragraph 0286; 0287, (2015/03/16)
The present invention relates to compounds formula (I): and to salts thereof, wherein R1-R4 and A have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of histone demethylases, such as KDM5. Also included are pharmaceutically acceptable compositions comprising the compounds of the present invention and methods of using said compositions in the treatment of various disorders.
Facile preparation of cyclopropanes from 2-iodoethyl-substituted olefins and 1,3-dihalopropanes with zinc powder
Sakuma, Daisuke,Togo, Hideo
, p. 10138 - 10145 (2007/10/03)
Two efficient, simple, cheap, and environmentally benign preparations of cyclopropanes were achieved. One is the formation via 3-exo-trig manner from various electron-deficient 2-iodoethyl-substituted olefins with zinc powder in a mixture of t-butyl alcoh
