59726-37-3

Upstream product

• 18995-13-6 Diethyl ethylsodiomalonate 
• 106-95-6 allyl bromide 
• 2049-80-1 (2-propenyl)propanedioic acid diethyl ester 
• 75-03-6 ethyl iodide 
• 105-53-3 diethyl malonate 
• 174619-42-2 diethyl (+/-)-(2-bromoethyl)(2-propenyl)propanedioate 
• 133-13-1 ethyl diethyl malonate 

Downstream Products

• 500534-89-4 5-ethyl-5-allyl-2-thio-barbituric acid 
• 89221-45-4 α-o-amino-m-chlorophenylaminocarbonyl-α-ethyl-γ-valerolactone 
• 90566-28-2 5-Ethyl-5-(β-hydroxy-propyl)-barbitursaeure 
• 105985-98-6 2-Ethyl-pent-4-enoic acid 3-phenoxy-benzyl ester 
• 1575-73-1 2-ethyl-pent-4-enoic acid 
• 2373-84-4 5-allyl-5-ethylbarbital 

Relevant academic research and scientific papers

Copper-Catalyzed Dicarbofunctionalization of Unactivated Olefins by Tandem Cyclization/Cross-Coupling

We present a strategy that difunctionalizes unactivated olefins in 1,2-positions with two carbon-based entities. This method utilizes alkyl/arylzinc reagents derived from olefin-tethered alkyl/aryl halides that undergo radical cyclization to generate C(sp3)-Cu complexes in situ, which are intercepted with aryl and heteroaryl iodides. A variety of (arylmethyl)carbo- and heterocycles (N, O) can be synthesized with this new method.

SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS

Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.