5980-24-5

Usage

Uses

Used in Pesticide Industry:
2,3-Dichlorobenzamide is used as an active ingredient in pesticides for its potent herbicidal properties. It targets and eliminates a wide range of weeds, thereby safeguarding crops and enhancing agricultural productivity. Its effectiveness in controlling plant growth makes it a valuable component in this industry.
Used in Pharmaceutical Production:
As an intermediate in the synthesis of pharmaceuticals, 2,3-Dichlorobenzamide contributes to the creation of essential drugs. Its chemical structure allows for further reactions and modifications, enabling the development of new and improved medicinal compounds that address various health concerns.
Used in Organic Compounds Synthesis:
2,3-Dichlorobenzamide is utilized as a key intermediate in the production of other organic compounds. Its unique properties facilitate the synthesis of a variety of chemical products, expanding its applications across different industries.
However, it is important to note that 2,3-Dichlorobenzamide is classified as a potential environmental pollutant due to its persistence in soil and its ability to contaminate water sources. It poses a risk to aquatic organisms and requires careful management to minimize its harmful effects on the environment. Additionally, it is a known irritant to the skin, eyes, and respiratory system, necessitating proper handling and safety measures to prevent exposure.

InChI:InChI=1/C7H5Cl2NO/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H2,10,11)

Upstream product

• 2905-60-4 2,3-dichlorobenzoyl chloride 
• 50-45-3 2,3-dichlorbenzoic acid 
• 57-13-6 urea 
• 79-37-8 oxalyl dichloride 
• 608-27-5 2,3-dichloroaniline 
• 6574-97-6 2,3-dichlorobenzonitrile 

Downstream Products

• 84863-83-2 2,3-dichlorobenzothioamide 
• 936220-57-4 2,3-dichloro-N-[(dimethylamino)methylene]benzamide 
• 104326-71-8 ethyl 2,3-dichlorobenzimidate 
• 2905-60-4 2,3-dichlorobenzoyl chloride 
• 181283-33-0 3-amino-2-carbomethoxy-7-chloro-benzothiophene 
• 6574-97-6 2,3-dichlorobenzonitrile 
• 50-45-3 2,3-dichlorbenzoic acid 

Relevant academic research and scientific papers

Design, synthesis and fungicidal activity of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamide

To find a new lead compound with high biological activity, a series of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamide were designed using linking active substructures method. The target compounds were synthesized from substituted benzoic acid by four steps and their structures were confirmed by 1H NMR, IR spectrum and elemental analysis. The in vitro bioassay results indicated that some target compounds exhibited excellent fungicidal activities, and the position of the substituents played an important role in fungicidal activities. Especially, compound 5n, exhibited better fungicidal activities than the commercial fungicide flutolanil against two tested fungi Valsa Mali and Sclerotinia sclerotiorum, with EC50 values of 3.44 and 2.63 mg/L, respectively. And it also displayed good in vivo fungicidal activity against S. sclerotiorum with the EC50 value of 29.52 mg/L.

REMEDIES FOR STRESS DISEASES COMPRISING MITOCHONDRIAL BENZODIAZEPINE RECEPTOR ANTAGONISTS

A pharmaceutical composition for the prophylaxis and/or treatment of diseases induced, exacerbated or reignited by stressors comprising the compound of formula (I) wherein all symbols have the same meanings as described in the specification, etc. as an active ingredient.

Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole α(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH)

In search of a uroselective agent that exhibits a high level of selectivity for the α(1A) receptor, a novel series of tricyclic hexahydrobenz[e]isoindoles was synthesized. A generic pharmacophoric model was developed requiring the presence of a basic amine core and a fused heterocyclic side chain separated by an alkyl chain. It was shown that the 6- OMe substitution with R, R stereochemistry of the ring junction of the benz[e]isoindole and a two-carbon spacer chain were optimal. In contrast to the highly specific requirements for the benz[e]isoindole portion and linker chain, a wide variety of tricyclic fused heterocyclic attachments were tolerated with retention of potency and selectivity. In vitro functional assays for the α1 adrenoceptor subtypes were used to further characterize these compounds, and in vivo models of vascular vs prostatic tone were used to assess uroselectivity.

TRICYCLIC SUBSTITUTED HEXAHYDROBENZ [E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS

The present invention relates to a compound of the formula STR1 and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an α-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are . alpha.-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.

3,3'-Bis-methylene-1,3-benzo-thiazine compounds

3,3'-Bis-Methylene-1,3-benzothiazine compounds are inhibitors of phenylethanolamine N-methyl-transferase.