5982-99-0

Basic information

• Product Name: androstane-3,17-dione
• Synonyms: Androsta-3,17-dione
• CAS NO: 5982-99-0
• Molecular Formula: C₁₉H₂₈O₂
• Molecular Weight: 288.42
• Mol File: 5982-99-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 132-133 °C
• Boiling Point: 411.2°C at 760 mmHg
• Flash Point: 153.9°C
• Appearance: /
• Density: 1.079g/cm³
• Vapor Pressure: 5.68E-07mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: androstane-3,17-dione(CAS DataBase Reference)
• NIST Chemistry Reference: androstane-3,17-dione(5982-99-0)
• EPA Substance Registry System: androstane-3,17-dione(5982-99-0)

Safety Data

• Hazardous Substances Data: 5982-99-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12?,14-,15-,16-,18-,19-/m0/s1

Upstream product

• 58-22-0 testosterone 
• 571-20-0 (5S,10R,13R)-10,13-Dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,17-diol 
• 571-20-0 (5R,10R,13R)-10,13-Dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,17-diol 
• 53-43-0 dehydroepiandrosterone 
• 571-20-0 (5α)-androstane-3β,17β-diol 
• 3591-19-3 (5S,10S,13S,14S)-3,3-Dimethoxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one 
• 4966-70-5 Androsten-⁽⁵⁾-dion-(3,17)-bis-aethylenacetal 
• 63-05-8 4-androstene-3,17-dione 
• 53-41-8 androsterone 
• 53-41-8 epiandrosterone 
• 571-20-0 (3S,5S,10S,13S)-10,13-Dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,17-diol 

Downstream Products

• 571-39-1 androstenedione 
• 3591-19-3 3-bismethoxyandrost-17-one 
• 63-05-8 (8R,9S,10R,13S)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione 
• 24887-75-0 androstane 
• 571-39-1 Androst-1-en-3,17-dion 

Relevant articles and documents

Method for synthesizing stanozolol intermediate androstane-17alpha-methyl-17beta-hydroxyl-3-ketone

The invention provides a method for synthesizing a stanozolol intermediate androstane-17alpha-methyl-17beta-hydroxyl-3-ketone. The method comprises the following steps: taking 4-androstenedione as a raw material, carrying out 3-site and 17-site keto-double-ketal, 5-site ethylenic bond catalytic hydrogenation and 3-site and 17-site double-ketal hydrolysis to prepare a compound 5alpha-androstane-3,17-diketone; then carrying out 3-site keto-double-etherification and 17-site Grignard addition, and finally carrying out hydrolysis to prepare the compound androstane-17alpha-methyl-17beta-hydroxyl-3-ketone, wherein the HPLC (High Performance Liquid Chromatography) purity of the compound is 99.0% or greater. The method provided by the invention is short in route, easy in production process control,environmentally-friendly, low in production cost and applicable to industrial large-scale production.

Highly efficient chemoselective deprotection of O,O-acetals and O,O-ketals catalyzed by molecular iodine in acetone

An extremely convenient method for deprotection of acetals and ketals catalyzed by molecular iodine (10 mol %) in acetone is reported. The protocol achieved the deprotection of acyclic or cyclic O,O-acetals and O,O-ketals in excellent yields within a few minutes under neutral conditions. The double bond, hydroxyl group, and acetate group remained unchanged, and the highly acid-sensitive furyl, tert-butyl ethers, and ketone-oxime stayed intact under these conditions.

CHEMOSELECTIVITY IN MOLYBDENUM CATALYZED ALCOHOL AND ALDEHYDE OXIDATIONS

Hydrogen peroxide in the presence of (NH4)6Mo7O24*4H2O and potassium carbonate is a chemoselective method to oxidize secondary alcohols to ketones and to oxidize aldehydes to acids, the latter also accelerated by cerium chloride.