599-87-1

Basic information

• Product Name: 4-CHLORO-N-(4-CHLOROPHENYL)BENZENESULFONAMIDE
• Synonyms: 4-CHLORO-N-(4-CHLOROPHENYL)BENZENESULFONAMIDE;N-(4-CHLOROPHENYL)-4-CHLOROBENZENSULFONAMIDE
• CAS NO: 599-87-1
• Molecular Formula: C₁₂H₉Cl₂NO₂S
• Molecular Weight: 302.18
• Mol File: 599-87-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 145.4-146 °C
• Boiling Point: 430.3 °C at 760 mmHg
• Flash Point: 214 °C
• Appearance: /
• Density: 1.492 g/cm³
• Vapor Pressure: 1.31E-07mmHg at 25°C
• Refractive Index: 1.647
• PKA: 7.33±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-N-(4-CHLOROPHENYL)BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-N-(4-CHLOROPHENYL)BENZENESULFONAMIDE(599-87-1)
• EPA Substance Registry System: 4-CHLORO-N-(4-CHLOROPHENYL)BENZENESULFONAMIDE(599-87-1)

Safety Data

• Hazardous Substances Data: 599-87-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H9Cl2NO2S/c13-9-1-5-11(6-2-9)15-18(16,17)12-7-3-10(14)4-8-12/h1-8,15H

Upstream product

• 106-47-8 4-chloro-aniline 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 98-64-6 4-Chlorobenzenesulfonamide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 30066-82-1 N-chloro-p-chlorobenzenesulfonamide sodium salt 
• 4547-68-6 p-chlorobenzenesulfonyl azide 
• 183440-84-8 4-Chloro-benzenesulfonic acid cyano-dimethyl-methyl ester 
• 64-17-5 ethanol 
• 134899-48-2 4-Chloro-N-(4-chloro-phenyl)-N-{1-[(E)-3-nitro-phenylimino]-ethyl}-benzenesulfonamide 
• 129957-30-8 N¹-(p-chlorobenzenesulfonyl)-N¹,N²-di(p-chlorophenyl)acetamidine 

Downstream Products

• 631-93-6 4-chloro-benzenesulfonic acid-(4-chloro-N-methyl-anilide) 
• 10589-67-0 4,4'-dichloro-2'-nitrobenzenesulfonanilide 
• 920011-89-8 N-{1-[2-(3-bromo-propoxy)-phenyl]-ethyl}-4-chloro-N-(4-chloro-phenyl)-benzenesulfonamide 
• 104094-54-4 4-chloro-benzenesulfonic acid-(4,N-dichloro-anilide) 
• 601-72-9 4-chloro-benzenesulfonic acid-(N-ethyl-4-chloro-anilide) 

Relevant articles and documents

Synthesis of N -Arylsulfonamides by a Copper-Catalyzed Reaction of Chloramine-T and Arylboronic Acids at Room Temperature

A copper-catalyzed Chan-Lam-coupling-like reaction of a (het)arylboronic acid and chloramine-T (or a related compound) has been developed for the synthesis of N -arylsulfonamides at room temperature in moderate to good yields, with good tolerance of functional groups. In this process, it is believed that chloramine-T serves as an electrophile.

A highly efficient heterogeneous copper-catalyzed Chan-Lam coupling reaction of sulfonyl azides with arylboronic acids leading to: N -arylsulfonamides

A heterogeneous Chan-Lam coupling reaction between sulfonyl azides and arylboronic acids was achieved in MeOH at room temperature in the presence of 10 mol% of an l-proline-functionalized MCM-41-immobilized copper(i) complex [MCM-41-l-proline-CuCl] under air, yielding a variety of N-arylsulfonamides in excellent yields. The new heterogeneous copper complex can be prepared from commercially readily available and inexpensive reagents, and recovered by simple filtration of the reaction solution and recycled at least 8 times without any decreases in activity.

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

Synthesis and biological evaluation of an arylsulfonamide class of γ-secretase inhibitors are described. Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported.