16013-14-2

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Nitrophenyl)-1,2,4-oxadiazole is used as a building block for the synthesis of various organic compounds, particularly in the development of pharmaceuticals. Its diverse biological activities, such as antimicrobial, antiviral, anti-inflammatory, and anticancer properties, make it a promising candidate for the creation of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 3-(4-nitrophenyl)-1,2,4-oxadiazole is utilized as a component in the synthesis of agrochemicals, contributing to the development of new pesticides, herbicides, and other agricultural chemicals that can improve crop protection and yield.
Used in Environmental Monitoring:
3-(4-Nitrophenyl)-1,2,4-oxadiazole has been studied for its potential as a fluorescent probe for detecting metal ions and as a sensor for environmental pollutants. Its ability to interact with specific ions and contaminants makes it a valuable tool for environmental analysis and monitoring.
Used in Material Science:
In the field of material science, 3-(4-nitrophenyl)-1,2,4-oxadiazole is employed in the development of new materials with unique properties. Its incorporation into various materials can enhance their performance, making them suitable for a wide range of applications, from electronics to advanced coatings.
Overall, 3-(4-nitrophenyl)-1,2,4-oxadiazole is a versatile and valuable chemical compound with a broad spectrum of potential uses across different industries, making it an essential component in research and development efforts.

Upstream product

• 5157-62-0 3-phenyl-1,2,4-oxadiazole 
• 1613-86-1 N-hydroxy-4-nitrobenzamidine 
• 122-51-0 orthoformic acid triethyl ester 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 192332-48-2 N'-hydroxy-4-nitrobenzimidamide 
• 1011-84-3 4-nitrobenzohydroximoyl chloride 
• 1613-86-1 p-nitrophenylamidoxime 
• 619-72-7 4-nitrobenzonitrile 
• 114006-44-9 (4-Nitro-phenyl)-tetrazol-1-yl-methanone oxime 

Downstream Products

• 841301-32-4 N-(2-((4-(1,2,4-oxadiazol-3-yl)phenyl)amino)-2-oxoethyl)-N-(2,6-dimethylphenyl)tetrahydro-2H-thiopyran-4-carboxamide 1,1-dioxide 
• 59908-71-3 <4-(1,2,4-oxadiazol-3-yl)phenyl>carbamic acid methyl ester 
• 96898-47-4 [1-(4-Chloro-3-nitro-phenyl)-meth-(E)-ylidene]-(4-[1,2,4]oxadiazol-3-yl-phenyl)-amine 
• 96898-48-5 [1-(5-Nitro-furan-2-yl)-meth-(E)-ylidene]-(4-[1,2,4]oxadiazol-3-yl-phenyl)-amine 
• 96898-46-3 3-<4-<<(4-chlorophenyl)methylene>amino>phenyl>-1,2,4-oxadiazole 
• 96898-49-6 (4-[1,2,4]Oxadiazol-3-yl-phenyl)-[1-(1H-pyrrol-2-yl)-meth-(E)-ylidene]-amine 
• 54608-86-5 5-(4-isothicyanatophenyl)-1,2,4-oxadiazole 
• 59908-72-4 [4-(1,2,4-Oxadiazol-3-yl)phenyl]carbamic acid, phenyl ester 
• 59908-73-5 (4-[1,2,4]oxadiazol-3-yl-phenyl)-carbamic acid 2,2,2-trichloro-ethyl ester 
• 59908-70-2 4-[1,2,4]oxadiazol-3-yl-phenylamine 

Relevant academic research and scientific papers

NEW PROCESS FOR THE PREPARATION OF AMENAMEVIR

The present invention relates to an improved process for the preparation of Amenamevir and derivatives thereof via a four component Ugi reaction.

Iron(III) Chloride/l-Proline as an Efficient Catalyst for the Synthesis of 3-Substituted 1,2,4-Oxadiazoles from Amidoximes and Triethyl Orthoformate

A general, facile, and efficient method is presented for the synthesis of 3-substituted 1,2,4-oxadiazoles from amidoximes and triethyl orthoformate. The procedure employs an iron(III) chloride/l-proline catalytic system and the 3-substituted 1,2,4-oxadiaz

THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

HYDRAZONE DERIVATIVE

A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof

An approach to pyrimidine N-oxides: Carboxamide oximes as precursors

A method for the synthesis of pyrimidines N-oxides is described. Various carboxamide oximes were treated with the appropriate 1,3-dicarbonyl compounds or their equivalents in the presence of trifluoroacetic acid as a catalyst to give the corresponding pyr

SYNTHESIS AND THERMOLYSIS OF SOME N-HYDROXIMOYL- AND N-HYDRAZONOYLAZOLES

The reactions of nitrile oxides or nitrile imines with pyrazole, imidazole, 1,2,3- and 1,2,4-triazole or tetrazole derivatives yield the appropriate N-hydroximoyl- or N-hydrazonoylazoles.Thermolysis of 1-hydroximoyltetrazoles, depending on the nature of the substituents in the tetrazole ring, yields 1,2,4-oxadiazoles or 5-amino-1,2,4-oxadiazoles upon hydrazoic acid or nitrogen evolution.Under similar conditions, 1-hydrazonoyltetrazoles give 1,2,4-triazoles or 5-amino-1,2,4-triazoles while 2-hydrazonoyltetrazoles decompose to the dihydro-1,2,4,5-tetrazine derivatives.

Antiparasitic Agents. 6. Synthesis and Anthelmintic Activities of Novel Isothiocyanatophenyl-1,2,4-oxadiazoles

The syntheses and anthelmintic activities of 31 3- and 5-(isothiocyanatophenyl)-1,2,4-oxadiazoles are reported.In the primary anthelmintic screen, 3-(4-isothiocyanatophenyl)-1,2,4-oxadiazole (39) showed 100percent nematocidal activity and 3-(2-furanyl)-5-

[(1,2,4-Oxadiazol-3-yl)phenyl]carbamic or thiocarbamic acid esters

Compounds of the formula STR1 and their acid-addition salts wherein X is O or S; R is hydrogen, lower alkyl, phenyl, chloro, bromo, trifluoromethyl, lower alkoxy, phenoxy, or di(lower alkyl)amino; R1 is hydrogen, lower alkyl, phenyl, substitute