59974-40-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-chlorophenyl)adamantane is used as an antiviral agent for its potential to combat viral infections due to its unique chemical structure and properties.
1-(4-chlorophenyl)adamantane is used as an antineoplastic (anticancer) agent for its potential to inhibit cancer cell growth and proliferation, making it a promising candidate for further research and development in cancer treatment.
1-(4-chlorophenyl)adamantane is used as a neurotransmitter reuptake inhibitor for its potential effects on the central nervous system, which could be beneficial in the treatment of various neurological and psychiatric disorders.
Used in Research and Development:
1-(4-chlorophenyl)adamantane is used as a chemical compound in the research and development of new pharmaceuticals, given its unique structure and potential applications in various therapeutic areas.

Upstream product

• 281-23-2 adamantane 
• 108-90-7 chlorobenzene 
• 106-39-8 bromochlorobenzene 
• 57680-77-0 adamantylmagnesium bromide 
• 768-90-1 1-Adamantyl bromide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 1459-48-9 4-(tricyclo[3.3.1.1^3,7]dec-1-yl)aniline 

Relevant academic research and scientific papers

Organic compound and device and electronic device using the same

The invention belongs to the technical field of organic electroluminescent materials, and particularly relates to a carbazole organic compound with an adamantyl substituent. The organic compound provided by the invention can be used as an organic electroluminescent layer material of an organic electroluminescent device, can reduce the luminescent voltage of the organic electroluminescent device, improves the luminescent efficiency of the device and prolongs the service life of the device.

Method for producing aminoaryladamantane (by machine translation)

PROBLEM TO BE SOLVED: dihalogenononadiene intermediate body, or of a material suitably used as a raw material for aminoaryladamantane a manufacturing method suitable for industrial production. SOLUTION: adamanatanes, and aromatic compound by reacting a mixture of sulfuric acid, or a halide, such as raw adamanatanes adamanatanes hydroxyacid available requiring time or cost without using a raw material, which does not have these substituents in one stage from adamanatanes aminoaryladamantane can be produced. Selected drawing: no (by machine translation)

Indium-catalyzed Friedel-crafts Alkylation of monosubstituted benzenes by 1-bromoadamantane

Indium salts such as InCl3 and InBr3 (ca. 1-5 mol%) efficiently catalyzed the Friedel-Crafts reaction of 1-bromoadamantane with benzene and monosubstituted benzenes to give 1-adamantyl benzenes. Indium bromide enabled faster reaction

Nickel-catalyzed cross-coupling of aryl bromides with tertiary grignard reagents utilizing donor-functionalized N-heterocyclic carbenes (NHCs)

Metal-catalyzed cross-coupling reactions are among the most important transformations in organic synthesis, allowing the efficient construction of complex structures from simpler, readily available building blocks.Many applications in large and small-scale synthesis can be found in different areas such as agrochemicals, pharmaceuticals and supramolecular chemistry. Whereas the coupling of sp2-hybridized carbon atoms in either reaction partner is well established, the use of CACHTUNGTRENUNG(sp3)-hybridized substrates presents some challenges. Catalytic cross-coupling of sterically hindered tertiary alkyl substrates is especially difficult, generally resulting in low yields, and thus, only few reports exist.[27] A big challenge in this field is not only to get the required level of reactivity, but also to overcome competing pathways like β-hydride elimination, hydrodehalogenation or isomerization

Palladium-Catalyzed Coupling Reactions of 1-Bromoadamantane with Styrenes and Arenes

The palladium-catalyzed reaction of 1-bromoadamantane (1-Br) with styrene and donor-substituted styrenes gave the corresponding Heck-type coupling products 3a and b, and 5a and b in moderate yields (15-41percent), while the reaction of 1-Br with various arenes 6a-p under palladium catalysis gave the corresponding adamantyl-substituted arenes 7a-p in good to excellent yields (35-98percent). - Keywords: cross-coupling reactions; metal-catalyzed/adamantylation of styrene and alkenes/arylation of 1-bromoadamantane/Heck reaction; palladium catalysis

Direct Clay-Catalyzed Friedel-Crafts Arylation and Chlorination of the Hydrocarbon Adamantane

Multiple chlorinations and arylations at the tertiary positions of adamantane are promoted by FeCl3-doped K10 montmorillonite in CCl4 or in aromatic solvents.The process, remarkably easy implement, can be tailored to selective formation of monosubstituted 1-adamantyl derivatives or 1,3-disubstituted adamantanes.The process achieves alkylation at the meta- and para-positions of toluene leading to a purely statistical distribution and displays no substrate specificity in competition experiments between toluene and benzene.