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  • 600-90-8 Structure
  • Basic information

    1. Product Name: Epiprednisolone
    2. Synonyms: Epiprednisolone;Prednisolone EP Impurity F (11-Epi-prednisolone);Prednisone impurity F (EP);Prednisolone EP Impurity F;(8S,9S,10R,11R,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
    3. CAS NO:600-90-8
    4. Molecular Formula: C21H28O5
    5. Molecular Weight: 360.44402
    6. EINECS: N/A
    7. Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
    8. Mol File: 600-90-8.mol
    9. Article Data: 3
  • Chemical Properties

    1. Melting Point: 222-223 °C
    2. Boiling Point: 570.6±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.31±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: -20°C Freezer
    8. Solubility: Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly,
    9. PKA: 12.46±0.70(Predicted)
    10. CAS DataBase Reference: Epiprednisolone(CAS DataBase Reference)
    11. NIST Chemistry Reference: Epiprednisolone(600-90-8)
    12. EPA Substance Registry System: Epiprednisolone(600-90-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 600-90-8(Hazardous Substances Data)

600-90-8 Usage

Description

Epiprednisolone, a derivative of prednisolone (P703740), is a synthetic corticosteroid that is metabolically interconvertible with prednisone. It exhibits potent anti-inflammatory and immunosuppressive properties, making it a valuable compound in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
Epiprednisolone is used as an anti-inflammatory and immunosuppressive agent for the treatment of various conditions, including autoimmune diseases, allergies, and skin disorders. Its ability to suppress the immune system and reduce inflammation makes it an effective treatment option for a wide range of medical conditions.
Epiprednisolone is also used as a prednisolone impurity in the synthesis and quality control of prednisolone, ensuring the purity and efficacy of the final product. This application is crucial in maintaining the safety and effectiveness of prednisolone-based medications.

Check Digit Verification of cas no

The CAS Registry Mumber 600-90-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 0 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 600-90:
(5*6)+(4*0)+(3*0)+(2*9)+(1*0)=48
48 % 10 = 8
So 600-90-8 is a valid CAS Registry Number.

600-90-8Downstream Products

600-90-8Relevant articles and documents

Dehalogenation methodof 9-halogenated steroid compound and application

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Paragraph 0149-0151, (2021/01/11)

The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.

Steroid transformations with Exophiala jeanselmei var. lecanii-corni and Ceratocystis paradoxa

Porter, Roy B.R.,Gallimore, Winklet A.,Reese, Paul B.

, p. 770 - 779 (2007/10/03)

The fungi Exophiala jeanselmei var. lecanii-corni [IMI (International Mycological Institute) 312989, UAMH (University of Alberta Microfungus Collection and Herbarium) 8783] and Ceratocystis paradoxa (IMI 374529, UAMH 8784) have been examined for their potential in steroid biotransformation. The study has determined that E. jeanselmei var. lecanii-corni effected overall anti-Markovnikov hydration on dehydroisoandrosterone, and side-chain degradation on a variety of pregnanes. Both ascomycetes were found to carry out redox reactions of alcohols and ketones as well as 1,4 reduction of α,β-unsaturated carbonyl systems.

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