600-90-8

Basic information

• Product Name: Epiprednisolone
• Synonyms: Epiprednisolone;Prednisolone EP Impurity F (11-Epi-prednisolone);Prednisone impurity F (EP);Prednisolone EP Impurity F;(8S,9S,10R,11R,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
• CAS NO: 600-90-8
• Molecular Formula: C₂₁H₂₈O₅
• Molecular Weight: 360.44402
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 600-90-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 222-223 °C
• Boiling Point: 570.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.31±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly,
• PKA: 12.46±0.70(Predicted)
• CAS DataBase Reference: Epiprednisolone(CAS DataBase Reference)
• NIST Chemistry Reference: Epiprednisolone(600-90-8)
• EPA Substance Registry System: Epiprednisolone(600-90-8)

Safety Data

• Hazardous Substances Data: 600-90-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 600-90-8 differently. You can refer to the following data:
1. Epiprednisolone is a derivative of prednisolone (P703740), synthetic corticosteroid; metabolically interconvertible with prednisone.
2. Epiprednisolone (Prednisolone EP Impurity F) is a derivative of prednisolone (P703740), synthetic corticosteroid; metabolically interconvertible with prednisone.

Upstream product

• 1249-67-8 17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate 
• 640-87-9 cortexolone 21-acetate 
• 53-03-2 Prednison 
• 566-35-8 Epicortisol 
• 1807-14-3 17α,21-dihydroxypregna-1,4-diene-3,20-dione 
• 30934-01-1 17α-Hydroxy-pregna-1,4,9(11)-dien-3,20-dion 

Relevant articles and documents

Dehalogenation methodof 9-halogenated steroid compound and application

The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.

Steroid transformations with Exophiala jeanselmei var. lecanii-corni and Ceratocystis paradoxa

The fungi Exophiala jeanselmei var. lecanii-corni [IMI (International Mycological Institute) 312989, UAMH (University of Alberta Microfungus Collection and Herbarium) 8783] and Ceratocystis paradoxa (IMI 374529, UAMH 8784) have been examined for their potential in steroid biotransformation. The study has determined that E. jeanselmei var. lecanii-corni effected overall anti-Markovnikov hydration on dehydroisoandrosterone, and side-chain degradation on a variety of pregnanes. Both ascomycetes were found to carry out redox reactions of alcohols and ketones as well as 1,4 reduction of α,β-unsaturated carbonyl systems.