60031-47-2Relevant academic research and scientific papers
Pyrazolopyridine compound and use thereof
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Paragraph 0420; 0426; 0427, (2018/11/03)
The present invention relates to a pyrazolopyridine compound and use thereof, and further relates to a pharmaceutical composition comprising the pyrazolopyridine compound. The pyrazolopyridine compound or the pharmaceutical composition can be used as a so
4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS
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Page/Page column 643, (2016/06/14)
The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
Synthesis of 3-Substituted-1-methylpyrazoles
Pavlik, James W.,Kurzweil, Edyth M.
, p. 1357 - 1359 (2007/10/02)
Reaction of 3-bromo-1-methylpyrazole 1 with t-butyllithium at -100 deg C followed by quenching of the lithiopyrazole intermediate allows regiospecific introduction of substituents into the 3-position of the 1-methylpyrazole ring.
