6005-95-4Relevant academic research and scientific papers
An improved procedure for α-methylenation of lactones
Murta,De Azevedo,Greene
, p. 495 - 503 (2007/10/02)
A variety of γ-butyrolactones, as well as a δ-valerolactone and an ester, have been efficiently converted to their α-methylene derivatives by using an improved decarboxylative methylenation procedure, which is simpler and more general than the previously
Synthese et etude pharmacologique de quelques aminolactones et aminotetrahydrofuranes adamantaniques
Foscolos, GB,Fytas, G,Kolocouris, N,Vamvakides, A
, p. 59 - 67 (2007/10/02)
This paper describes the synthesis of adamantane aminolactones (AdAL 6 and PhAdAL 16) and their tetrahydrofuran analogues (AdAE 9 and PhAdAE 19).Their convulsant activity was studied in mice.It was found to be weaker than that of the aminolactones or aminotetrahydrofurans, which have a phenyl group in place of the adamantane ring.Studies on the antagonism of the convulsant action of these derivatives, by GABAergic or glycinergic agonists appear to show the simultaneous development of dopaminergic, antiGABAergic (for the AdAE and PhAdAE) and antiglycinergic (for theAdAL and PhAdAL) central activities.These properties could be interesting in the treatment of the late stages of the Parkinson's disease.
Reactions of Styrene Oxide with Some Active Hydrogen Compounds
Hashem, A. I.,Shaban, M. E.
, p. 807 - 808 (2007/10/02)
Styrene oxide reacts with diethyl malonate in the presence of sodium ethoxide to give the intermediate carboxylactones (IIa and IIb).Decarboxylation of the latter produces the corresponding butyrolactones (Ia and Ib).Styrene oxide also reacts with ethyl c
