60083-29-6Relevant academic research and scientific papers
Iodine-catalyzed diazenylation with arylhydrazine hydrochlorides in air
Barak, Dinesh S.,Dighe, Shashikant U.,Avasthi, Ilesha,Batra, Sanjay
, p. 3537 - 3546 (2018/04/14)
A mild approach to diazenylation of active methylene compounds and N-heterocyclic compounds with arylhydrazine hydrochlorides in the presence of iodine under basic aerobic conditions was developed. The reaction could be executed either under heating or in the presence of blue LED light, though the latter condition was found to be relatively efficient. Presumably, the aryldiazene produced by oxidation of arylhydrazine hydrochloride acts as a nitrogen scavenger of the radical intermediate generated from the active methylene compound in the presence of iodine to produce the diazo compounds. The scope and limitations of the protocol are presented.
Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene)alkanoic acids and related derivatives
Maggio, Benedetta,Raffa, Demetrio,Raimondi, Maria Valeria,Cascioferro, Stella,Plescia, Fabiana,Schillaci, Domenico,Cusimano, Maria Grazia,Leonchiks, Ainars,Zhulenkovs, Dmitrijs,Basile, Livia,Daidone, Giuseppe
, (2016/04/20)
A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for a carboxy, cyano or amide group, or introducing substituents in the phenyl ring of the ester and acid derivatives. The most active derivative found was 3-oxo-2-(2-(3,4dichlorophenyl)hydrazinylidene)butanoic acid (2b), showing an IC50 value of 50 μM. For a preliminary assessment of their antivirulence properties the new derivatives were tested for their antibiofilm activity. The most active compound resulted 2a, which showed inhibition of about 60% against S. aureus ATCC 29213, S. aureus ATCC 25923, S. aureus ATCC 6538 and S. epidermidis RP62A at a screening concentration of 100 μM.
Conversion of 2-Arylhydrazono-3-oxobutyronitrile and 2-Phenylhydrazonoethylbenzoylacetate into Heterocyclic Compounds
Bakeer, Hadeer Mohamed
, p. 314 - 317 (2007/10/02)
Several new heterocyclic compounds have been synthesized from 2-arylhydrazono-3-oxobutyronitrile (1a-d) and 2-phenylhydrazonoethylbenzoylacetate (10) as starting materials.
