60084-09-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl)-4-thiazolecarboxylic Acid Ethyl Ester is used as a protected intermediate for the synthesis of Tiazofurin (T437200), a potential therapeutic agent in the treatment of cancer. Its unique chemical structure allows for the development of novel cancer therapies that can target specific cellular pathways and mechanisms, offering new treatment options for patients with various types of cancer.
Used in Cancer Research:
2-(2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl)-4-thiazolecarboxylic Acid Ethyl Ester is used as a research tool in the study of cancer biology and the development of new cancer therapies. Its role as a protected intermediate in the synthesis of Tiazofurin (T437200) makes it a valuable compound for understanding the mechanisms of action and potential applications of this therapeutic agent in cancer treatment.
Used in Drug Development:
2-(2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl)-4-thiazolecarboxylic Acid Ethyl Ester is used in the development of new drugs and drug candidates for the treatment of cancer. Its unique chemical properties and potential therapeutic applications make it an important compound for drug discovery and development efforts, as researchers work to identify and optimize new cancer treatments.

InChI:InChI=1/C32H27NO9S/c1-2-38-32(37)23-19-43-28(33-23)27-26(42-31(36)22-16-10-5-11-17-22)25(41-30(35)21-14-8-4-9-15-21)24(40-27)18-39-29(34)20-12-6-3-7-13-20/h3-17,19,24-27H,2,18H2,1H3

Upstream product

• 57944-10-2 2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonthioamide 
• 70-23-5 ethyl Bromopyruvate 
• 98-88-4 benzoyl chloride 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 23316-67-8 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl-1-carbonitrile 
• 5517-61-3 methyl 3'-O-benzoyl-β-D-apiofuranoside 
• 52783-53-6 methyl 2,3,3'-tri-O-benzoyl-β-D-apiofuranoside 
• 4099-85-8 ((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 
• 5517-60-2 methyl 3'-O-benzoyl-2,3-O-isopropylidene-β-D-apiofuranoside 

Downstream Products

• 60084-11-9 2-(2',3'-O-isopropylidene-β-D-ribofuranosyl)thiazole-4-carboxamide 
• 60084-10-8 tiazofurin 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel apio nucleosides with thiazole-4-carboxamide and 1,2,4-triazole-3-carboxamide

In view of biological activities of azole nucleosides and apio-dideoxynucleoside, novel apio nucleoside analogues (1 and 2) with thiazole and triazole base moiety were synthesized using 2,3-O-isopropylidene-apio-β -D-furanose (3), which was prepared from D-mannose.

Method of producing tiazofurin and other C-nucleosides

C-nucleosides are synthesized by a method in which a sugar is derivatized in a single step to provide a heterocycle at the C1position, and then the heterocycle is aromatized in another single step. In one class of preferred embodiments a cyano

A modified synthesis of tiazofurin

An improved synthesis of tiazofurin is described from 1-O-acetyl-2,3,5- tri-O-benzoyl-β-D-ribofuranose.

Procedures for obtaining ribo-C-nucleosides

Novel procedures for obtaining ribo-C-nucleosides, including especially 2-β-D-ribofuranosylthiazole-4-carboxylamide (tiazofirin) and 2-β-D-ribofuranosylselenazole-4-carboxylamide (sylenazofurin) and synthesis intermediates thereof. The novel procedures in

Synthesis and antiviral activity of certain thiazole C nucleosides

A general reaction of glycosyl cyanides with liquid hydrogen sulfide in the presence of 4 dimethylaminopyridine to provide the corresponding glycosylthiocarboxamides is described. These glycosylthiocarboxamides were utilized as the precursors for the synt