60124-83-6

Basic information

• Product Name: ANTHRANILIC-3,4,5,6-D4 ACID
• Synonyms: ANTHRANILIC-3,4,5,6-D4 ACID;2-AMinobenzoic Acid-d4;Anthranilic Acid-d4
• CAS NO: 60124-83-6
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 141.16
• Product Categories: Aromatics;Intermediates;Isotope Labelled Compounds
• Mol File: 60124-83-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ANTHRANILIC-3,4,5,6-D4 ACID(CAS DataBase Reference)
• NIST Chemistry Reference: ANTHRANILIC-3,4,5,6-D4 ACID(60124-83-6)
• EPA Substance Registry System: ANTHRANILIC-3,4,5,6-D4 ACID(60124-83-6)

Safety Data

• Hazardous Substances Data: 60124-83-6(Hazardous Substances Data)

Usage

Uses

ANTHRANILIC-3,4,5,6-D4 ACID is used in the synthesis of labeled drugs of abuse for use as internal standards in quantification. ANTHRANILIC-3,4,5,6-D4 ACID is also used in the quantitative profiling of tryptophan metabolites.

Upstream product

• 118-92-3 anthranilic acid 
• 4165-61-1 aniline-d5 
• 54354-03-9 ethyl benzoate-d₅ 

Downstream Products

• 646502-89-8 2-fluorobenzoic acid-d₄ 

Relevant articles and documents

Incorporation of anthranilate-d4 into DIMBOA in maize

2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA) is synthesized in maize from anthranilic acid-d4 with high retention of deuterium. Retention of deuterium is only consistent with a mechanism of oxidative decarboxylation of o-carboxyanilinoribulose-5-phosphate or other anthranilate derivative via an intermediate in which oxygenation occurs at the carboxyl-bearing ortho carbon before decarboxylation

DEUTERATED SGC STIMULATORS

The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine onophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula I: or a pharmaceutically acceptable salt thereof, wherein each of Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8 and Y9 is independently selected from hydrogen and deuterium, as well as pharmaceutical compositions, methods and uses thereof.