60138-76-3

Basic information

• Product Name: 2-(DIMETHYLAMINO)NICOTINONITRILE
• Synonyms: 2-(DIMETHYLAMINO)NICOTINONITRILE;2-(dimethylamino)-pyridine-3-carbonitrile;3-pyridinecarbonitrile, 2-(dimethylamino)-;3-Cyano-2-dimethylaminopyridine;2--5-nitropyridine;2-(diMethylaMino)-3-Pyridinecarbonitrile
• CAS NO: 60138-76-3
• Molecular Formula: C8H9N3
• Molecular Weight: 147.17716
• Mol File: 60138-76-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 264.861ºC at 760 mmHg
• Flash Point: 113.984ºC
• Appearance: /
• Density: 1.113g/cm3
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Room temperature.
• PKA: 3.76±0.10(Predicted)
• CAS DataBase Reference: 2-(DIMETHYLAMINO)NICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(DIMETHYLAMINO)NICOTINONITRILE(60138-76-3)
• EPA Substance Registry System: 2-(DIMETHYLAMINO)NICOTINONITRILE(60138-76-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 60138-76-3(Hazardous Substances Data)

Usage

General Description

2-(Dimethylamino)nicotinonitrile is a chemical compound with the formula C8H10N2. It is a derivative of nicotinonitrile, a heterocyclic compound that is commonly used in the synthesis of pharmaceuticals and agrochemicals. 2-(Dimethylamino)nicotinonitrile is known for its potential use as a precursor in the synthesis of a variety of biologically active molecules, and it has been the subject of research in the development of new drugs. The compound has also been studied for its potential use as a building block in the synthesis of organic materials and as a catalyst in organic reactions. Additionally, it has been investigated for its potential use in the development of new materials for various applications. Overall, 2-(Dimethylamino)nicotinonitrile is a versatile compound with potential applications in a wide range of industries.

InChI:InChI=1/C8H9N3/c1-11(2)8-7(6-9)4-3-5-10-8/h3-5H,1-2H3

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 127-19-5 N,N-dimethyl acetamide 
• 3939-13-7 3-cyano-2-fluoropyridine 
• 24517-64-4 2-amino-3-pyridinecarbonitrile 

Downstream Products

• 354824-09-2 3-(aminomethyl)-N,N-dimethylpyridin-2-amine 

Relevant articles and documents

A Novel One-Pot Synthesis of N,N-Dimethylaminopyridines by Diazotization of Aminopyridines in Dimethylformamide in the Presence of Trifluoromethanesulfonic Acid

Abstract: Diazotization of aminopyridines in the presence of trifluoromethanesulfonic acid gives the corresponding pyridinyl trifluoromethanesulfonates instead of expected diazonium salts. Pyridinyl trifluoromethanesulfonates can be converted to N,N-dimethylaminopyridines on heating in dimethylformamide via replacement of the trifluoromethanesulfonyloxy group. The reaction is accelerated under microwave irradiation. A novel one-pot procedure has been proposed for the synthesis of 2- and 4-(dimethylamino)pyridines from commercially available aminopyridines. The procedure provides high yields of the target products, and it can be regarded as an alternative to the known methods of synthesis of N,N-dimethylpyridin-4-amine (DMAP) widely used as base catalyst in organic synthesis.

Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents

A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,Ndimethyl) amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts. Taylor & Francis Group, LLC.

Microwave-induced by-products in the synthesis of 2-(4-methyl-2-phenylpiperazinyl)pyridine-3-carbonitrile

The Letter describes the investigation of an industrial reaction of N-methylphenylpiperazine and chloronicotinonitrile, under microwave heating. Besides the formation of the expected 2-(4-methyl-2-phenylpiperazinyl)pyridine-3-carbonitrile (4), extension o