60141-31-3

Usage

Uses

Used in Pharmaceutical Industry:
5-(3-THIENYL)THIOPHENE-2-CARBOXYLIC ACID is used as a reactant for the preparation of antibacterial nitazoxanide-based analogs. These analogs have potential applications in the development of new drugs to combat bacterial infections, particularly those resistant to existing antibiotics.
Used in Chemical Synthesis:
In the field of chemical synthesis, 5-(3-THIENYL)THIOPHENE-2-CARBOXYLIC ACID can be utilized as a building block or intermediate for the creation of more complex organic molecules. Its unique structure with thiophene and thienyl rings allows for a variety of chemical reactions, making it a valuable component in the synthesis of advanced materials and compounds.
Used in Material Science:
The electronic properties of 5-(3-THIENYL)THIOPHENE-2-CARBOXYLIC ACID, due to its thiophene-based structure, make it a candidate for use in the development of organic electronic materials, such as organic semiconductors, conductive polymers, or sensors. Its potential applications in this industry could include the creation of new materials for use in solar cells, transistors, or other electronic devices.
Used in Research and Development:
As a novel organic compound, 5-(3-THIENYL)THIOPHENE-2-CARBOXYLIC ACID may be of interest to researchers in various fields, including chemistry, materials science, and pharmaceuticals. It can be used as a subject of study to explore new reactions, understand its properties, and potentially discover new applications or derivatives with beneficial characteristics.

Upstream product

• 62224-19-5 5-bromo-2-thiophenecarboxylic acid methyl ester 
• 1023531-76-1 C₁₀H₈O₂S₂ 
• 2404-89-9 2,3'-bithienyl 
• 124-38-9 carbon dioxide 
• 62224-20-8 2-bromothiophene-5-carboxylic acid tert-butyl ester 
• 1383629-03-5 tert-butyl 5-(3-thienyl)thiophene-2-carboxylate 
• 31555-60-9 5-bromothiophene-2-carbonyl chloride 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 

Relevant academic research and scientific papers

Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F

A series of dipeptide nitriles with different P3 substituents was designed to explore the S3 binding pocket of cathepsin S. Racemic 7-16 and the enantiopure derivative (R)-22 proved to be potent inhibitors of human cathepsin S and exhibited notable selectivity over human cathepsins L, K, and B. Inhibition of cathepsin F, the functional synergist of cathepsin S, was not observed. The azadipeptide analogue of 22, compound 26, was highly potent but nonselective.

Synthesis and Antimicrobial Evaluation of Nitazoxanide-Based Analogues: Identification of Selective and Broad Spectrum Activity

A library composed of nitazoxanide-based analogues was synthesized and assayed for increased antibacterial efficacy against the pyruvate-ferredoxin oxidoreductase (PFOR) using microorganisms Helicobacter pylori, Campylobacter jejuni and Clostridium difficile. Derivatives were found to recapitulate and improve activity against these organisms and select analogues were tested for their ability to disrupt the PFOR enzyme directly. The library was also screened for activity against staphylococci and resulted in the identification of analogues capable of inhibiting both staphylococci and all PFOR organisms at low micromolar minimum inhibitory concentrations with low toxicity to human foreskin cells. Hitting them where it hurts! A library of nitazoxanide-based analogues was synthesized and assayed for antibacterial efficacy against pyruvate-ferredoxin oxidoreductase (PFOR) utilizing microorganisms. Derivatives were found to recapitulate and improve activity against these organisms, and select analogues were screened for activity against staphylococci resulting in the identification of analogues capable of inhibiting both staphylococci and all PFOR organisms at low micromolar minimum inhibitory concentrations.