601512-75-8

Upstream product

• 28279-75-6 methyl 2-deoxy-3,5-di-O-benzoyl-2-fluoro-β-D-xylofuranoside 
• 108-24-7 acetic anhydride 
• 112245-59-7 methyl 3,5-O-isopropylidene-αβ-D-xylofuranoside 
• 1824-96-0 methyl xylofuranoside 
• 58-86-6 D-xylose 
• 64-19-7 acetic acid 

Downstream Products

• 601512-76-9 C₂₄H₂₁FN₂O₇ 
• 601512-77-0 C₂₄H₂₁FN₂O₇ 
• 601512-80-5 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-2-fluoro-β-D-xylofuranosyl]thymine 
• 163252-36-6 1-(2-deoxy-2-fluoro-α-D-xylofuranosyl)thymine 
• 601512-79-2 1-(2-deoxy-2-fluoro-β-D-xylofuranosyl)thymine 

Relevant academic research and scientific papers

MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF

The present disclosure provides oligomeric compounds comprising a modified oligonucleotide having at least one stereo-non-standard nucleoside. An oligomeric compound comprising a modified oligonucleotide consisting of 12-30 linked nucleosides, wherein at least one nucleoside of the modified oligonucleotide is a stereo-non-standard nucleoside; and wherein the oligomeric compound is selected from among an RNAi compound, a modified CRISPR compound, and an artificial mRNA compound.

Xylo-configured oligonucleotides (XNA, xylo nucleic acid): Synthesis of conformationally restricted derivatives and hybridization towards DNA and RNA complements

Xylo-Configured oligonucleotides (XNA) containing a novel conformationally restricted 2′-deoxy-2′-fluoro-β-D-xylofuranosyl nucleotide monomer, a novel conformationally locked 2′-amino-2′-deoxy-2′-N,4′-C-methylene-β-D- xylofuranosyl nucleotide monomer, and

xylo-configured oligonucleotides (XNA, xylo nucleic acids): Synthesis and hybridization studies

We report synthesis and high-affinity hybridization of fully modified home-thymine 2′-deoxy and 2′-deoxy-2′-fluoro xylo nucleic acids.