31491-37-9Relevant academic research and scientific papers
Synthesis of 3-fluoro-2,5-disubstituted furans through ring expansion ofgem-difluorocyclopropyl ketones
Amii, Hideki,Matsumura, Chihori,Sugiishi, Tsuyuka
, p. 3459 - 3462 (2020/05/25)
The synthesis of 3-fluoro-2,5-disubstituted furans fromgem-difluorocyclopropyl ketones was accomplished using trifluoromethanesulfonic acid (CF3SO3H) through ring expansion owing to the activation of the carbonyl group in the starting material. The present synthesis of 3-fluorofurans tolerates substrates designed for products with aromatic substituents at the C-2 and C-5 positions.
Au-catalyzed intramolecular hydroalkoxylation of gem-difluorinated alkynols
Hamel, Jean-Denys,Paquin, Jean-Fran?ois
, p. 11 - 23 (2018/10/20)
The intramolecular hydroalkoxylation of gem-difluorinated alkynols was found possible under Au catalysis, allowing for the preparation of a series of fluorinated heterocycles. The nature of the solvent was found to be especially critical in the cyclizatio
Synthesis of 3-fluoro-2,5-disubstituted furans and further derivative reactions to access fluorine-containing 3,3′-bifurans and tetrasubstituted furans
Li, Peng,Chai, Zhuo,Zhao, Gang,Zhu, Shi-Zheng
body text, p. 2547 - 2551 (2009/04/12)
2,5-Disubstituted 3-fluorofurans were synthesized in 42-99% yield via DBU-promoted cyclization reactions of electrondeficient gem- difluorohomopropargyl alcohols. Starting from these compounds, a series of fluorinated 3,3′-bifurans and tetrasubstituted fu
Ionic liquid, surrogate hydrogen bromide reagent for ring opening of cyclopropyl ketones
Xu, Wei,Dolbier Jr., William R.,Salazar, Jose
, p. 3535 - 3538 (2008/09/20)
(Chemical Equation Presented) Ionic liquid reagents created by addition of 1 equiv of either CF3CO2H or CF3SO3H to N-pentylpyridinium bromide exhibit excellent chemical reactivities as surrogate HBr reagents in ring-opening reactions of cyclopropyl ketones as well as of 2,2-difluorocyclopropyl ketones to form the respective 3-bromopropyl or 3-bromo-2,2-difluoropropyl ketones in good to excellent yields.
Selective synthesis of fluorinated furan derivatives via AgNO 3-catalyzed activation of an electronically deficient triple bond
Arimitsu, Satoru,Hammond, Gerald B.
, p. 8559 - 8561 (2008/02/12)
(Chemical Equation Presented) The transition metal-catalyzed direct activation of electron deficient triple bonds was investigated by using the combined electron withdrawing effects of two fluorine atoms to modulate the electronic density of the triple bo
A New and Concise Synthesis of 3-Fluoro-2,5-disubstituted Furans
Sham, Hing L.,Betebenner, David A.
, p. 1134 - 1135 (2007/10/02)
A highly efficient synthesis of a series of 3-fluoro-2,5-disubstituted furans by a two-step sequence is described.
