31491-37-9Relevant academic research and scientific papers
Synthesis of 3-fluoro-2,5-disubstituted furans through ring expansion ofgem-difluorocyclopropyl ketones
Amii, Hideki,Matsumura, Chihori,Sugiishi, Tsuyuka
, p. 3459 - 3462 (2020/05/25)
The synthesis of 3-fluoro-2,5-disubstituted furans fromgem-difluorocyclopropyl ketones was accomplished using trifluoromethanesulfonic acid (CF3SO3H) through ring expansion owing to the activation of the carbonyl group in the starting material. The present synthesis of 3-fluorofurans tolerates substrates designed for products with aromatic substituents at the C-2 and C-5 positions.
Au-catalyzed intramolecular hydroalkoxylation of gem-difluorinated alkynols
Hamel, Jean-Denys,Paquin, Jean-Fran?ois
, p. 11 - 23 (2018/10/20)
The intramolecular hydroalkoxylation of gem-difluorinated alkynols was found possible under Au catalysis, allowing for the preparation of a series of fluorinated heterocycles. The nature of the solvent was found to be especially critical in the cyclizatio
Ionic liquid, surrogate hydrogen bromide reagent for ring opening of cyclopropyl ketones
Xu, Wei,Dolbier Jr., William R.,Salazar, Jose
, p. 3535 - 3538 (2008/09/20)
(Chemical Equation Presented) Ionic liquid reagents created by addition of 1 equiv of either CF3CO2H or CF3SO3H to N-pentylpyridinium bromide exhibit excellent chemical reactivities as surrogate HBr reagents in ring-opening reactions of cyclopropyl ketones as well as of 2,2-difluorocyclopropyl ketones to form the respective 3-bromopropyl or 3-bromo-2,2-difluoropropyl ketones in good to excellent yields.
Synthesis of 3-fluoro-2,5-disubstituted furans and further derivative reactions to access fluorine-containing 3,3′-bifurans and tetrasubstituted furans
Li, Peng,Chai, Zhuo,Zhao, Gang,Zhu, Shi-Zheng
body text, p. 2547 - 2551 (2009/04/12)
2,5-Disubstituted 3-fluorofurans were synthesized in 42-99% yield via DBU-promoted cyclization reactions of electrondeficient gem- difluorohomopropargyl alcohols. Starting from these compounds, a series of fluorinated 3,3′-bifurans and tetrasubstituted fu
Selective synthesis of fluorinated furan derivatives via AgNO 3-catalyzed activation of an electronically deficient triple bond
Arimitsu, Satoru,Hammond, Gerald B.
, p. 8559 - 8561 (2008/02/12)
(Chemical Equation Presented) The transition metal-catalyzed direct activation of electron deficient triple bonds was investigated by using the combined electron withdrawing effects of two fluorine atoms to modulate the electronic density of the triple bo
A New and Concise Synthesis of 3-Fluoro-2,5-disubstituted Furans
Sham, Hing L.,Betebenner, David A.
, p. 1134 - 1135 (2007/10/02)
A highly efficient synthesis of a series of 3-fluoro-2,5-disubstituted furans by a two-step sequence is described.
